ArticleDiabetes care2013
Paternal metabolic and cardiovascular risk factors for fetal growth restriction: a case-control study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review on the role of paternal factors in human placental development, function, and pregnancy-related disorders.Journal of assisted reproduction and genetics · 2025Pooled it
- Relationship between paternal excessive weight and neonatal anthropometry in a clinical trial of nutritional counseling for pregnant women with overweight.International journal of obesity (2005) · 2024Trial
- Paternal Cardiometabolic Conditions and Perinatal Mortality.Paediatric and perinatal epidemiology · 2025Article
- Paternal family history of premature atherosclerotic disease and perinatal death: A population-based cohort study.PloS one · 2025Article
- Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Unlocking the Path to Healthier Families: The Untapped Potential of Men's Preconception Health.Journal of prevention (2022) · 2024Article
- The influence of insulin-related genetic variants on fetal growth, fetal blood flow, and placental weight in a prospective pregnancy cohort.Scientific reports · 2023Article
- Paternal Obesity Induced by High-Fat Diet Impairs the Metabolic and Reproductive Health of Progeny in Rats.Metabolites · 2023Article
- Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice.Clinical science (London, England : 1979) · 2021Article
- Effect of Preconception Care Intervention on Maternal Nutritional Status and Birth Outcome in a Low-Resource Setting: Proposal for a Nonrandomized Controlled Trial.JMIR research protocols · 2021Article
- Two decades since the fetal insulin hypothesis: what have we learned from genetics?Diabetologia · 2021Review
- Association between preconception paternal health and pregnancy loss in the USA: an analysis of US claims data.Human reproduction (Oxford, England) · 2021Article
- The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.PLoS genetics · 2020Article
- Paternal weight of ducks may have an influence on offspring' small intestinal function and cecal microorganisms.BMC microbiology · 2020Article
- Parental adiposity differentially associates with newborn body composition.Pediatric obesity · 2020Article
- Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review.PloS one · 2020Article
- Paternal Environmental Toxicant Exposure and Risk of Adverse Pregnancy Outcomes.Current obstetrics and gynecology reports · 2019Article
- Early-Life Exposures and Risk of Diabetes Mellitus and Obesity.Current diabetes reports · 2018Review
- Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice.Redox biology · 2015Article
- Relationships of maternal and paternal anthropometry with neonatal body size, proportions and adiposity in an Australian cohort.American journal of physical anthropology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFathers of low-birth weight offspring are more likely to have type 2 diabetes and cardiovascular disease in later life. We investigated whether paternal insulin resistance and cardiovascular risk factors were evident at the time that fetal growth-restricted offspring were born. RESEARCH DESIGN AND
methodsWe carried out a case-control study of men who fathered pregnancies affected by fetal growth restriction, in the absence of recognized fetal disease (n = 42), compared with men who fathered normal-birth weight offspring (n = 77). All mothers were healthy, nonsmoking, and similar in age, BMI, ethnicity, and parity. Within 4 weeks of offspring birth, all fathers had measures of insulin resistance (HOMA index), blood pressure, waist circumference, endothelial function (flow-mediated dilatation), lipid profile, weight, and smoking habit. Comparison was made using multivariable logistical regression analysis.
resultsFathers of fetal growth-restricted offspring [mean (SD) 1.8th (2.2) customized birth centile] were more likely to have insulin resistance, hypertension, central adiposity, and endothelial dysfunction and to smoke cigarettes compared with fathers of normal grown offspring. After multivariable analysis, paternal insulin resistance and smoking remained different between the groups. Compared with fathers of normal grown offspring, men who fathered pregnancies affected by fetal growth restriction had an OR 7.68 (95% CI 2.63-22.40; P < 0.0001) of having a 1-unit higher log HOMA-IR value and 3.39 (1.26-9.16; P = 0.016) of being a smoker.
conclusionsMen who recently fathered growth-restricted offspring have preclinical evidence of the insulin resistance syndrome and are more likely to smoke than fathers of normal grown offspring. Paternal lifestyle may influence heritable factors important for fetal growth.
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