Trial reportCirculation2013
Prospective, multicenter study of ventricular assist device infections.
Trial report in Circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01471795 (The Epidemiology of Ventricular Assist Device-Related Infections), which is not on this map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Epidemiology of Ventricular Assist Device-Related Infections
Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 256 citations in OpenAlex.
- Association between psychosocial factors and left ventricular assist device implant outcomes: A systematic review.General hospital psychiatryPooled it
- Left Ventricular Assist Device Infections: A Systematic Review.ASAIO journal (American Society for Artificial Internal Organs : 1992)Pooled it
- Preexisting Depression or Anxiety is Associated with Increased Wound Complications Following Breast Reduction Surgery: A Real-World Cohort Study.Aesthetic plastic surgery · 2026Article
- Comment on: Depression and Anxiety are Associated with Increased Complications after Penile prosthesis surgery: a retrospective cohort study.International journal of impotence research · 2026Article
- Depression and anxiety are associated with increased complications after penile prosthesis surgery: a retrospective cohort study.International journal of impotence research · 2026Article
- Determinants of Vitamin A Consumption Among Children Aged 6-23 Months in Somalia: A Multilevel Analysis of SDHS 2020.Food science & nutrition · 2025Article
- Vitamin D Deficiency and Driveline Infections in Patients With Left Ventricular Assist Devices.Artificial organs · 2025Article
- Driveline Relocation and Vacuum-Assisted Closure for Ventricular Assist Device Driveline Infections.Journal of cardiovascular development and disease · 2025Article
- Prospective evaluation of the Moleculight i:X™ in the early detection of driveline infections.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Infections in Patients with Mechanical Circulatory Support.Infectious disease clinics of North America · 2024Review
- Article
- Left ventricular assist device temporary explantation as a strategy for infection control in a pediatric patient.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Article
- In-vitro external fixation pin-site model proof of concept: A novel approach to studying wound healing in transcutaneous implants.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2024Article
- Epidemiology and Risk Factors for Nosocomial Infections in Left Ventricular Assist Device Recipients.Life (Basel, Switzerland) · 2024Article
- Postoperative care of 14 patients with left ventricular assist devices: a case series.The Journal of international medical research · 2024Article
- Risk factors for new antidepressant use after surgery in Sweden: a nationwide, observational cohort study.BJA open · 2023Article
- Mortality following durable left ventricular assist device implantation by timing and type of first infection.The Journal of thoracic and cardiovascular surgery · 2023Article
- Depression among Patients with an Implanted Left Ventricular Assist Device: Uncovering Pathophysiological Mechanisms and Implications for Patient Care.International journal of molecular sciences · 2023Review
- Driveline erosion of the colon as a late complication of LVAD implantation.Journal of cardiology cases · 2023Article
- Pre-operative risk factors for driveline infection in left ventricular-assist device patients.ESC heart failure · 2022Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundVentricular assist devices (VADs) improve survival and quality of life in patients with advanced heart failure, but their use is frequently complicated by infection. There are limited data on the microbiology and epidemiology of these infections. METHODS AND
resultsOne hundred fifty patients scheduled for VAD implantation were enrolled (2006-2008) at 11 US cardiac centers and followed prospectively until transplantation, explantation for recovery, death, or for 1 year. Eighty-six patients (57%) received HeartMate II devices. Data were collected on potential preoperative, intraoperative, and postoperative risk factors for infection. Clinical, laboratory, and microbiological data were collected for suspected infections and evaluated by an infectious diseases specialist. Thirty-three patients (22%) developed 34 VAD-related infections with an incidence rate of 0.10 per 100 person-days (95% confidence interval, 0.073-0.142). The median time to infection was 68 days. The driveline was the most commonly infected site (n=28); 18 (64%) were associated with invasive disease. Staphylococci were the most common pathogen (47%), but pseudomonas or other Gram-negative bacteria caused 32% of infections. A history of depression and elevated baseline serum creatinine were independent predictors of VAD infection (adjusted hazard ratio=2.8 [P=0.007] and 1.7 [P=0.023], respectively). The HeartMate II was not associated with a decreased risk of infection. VAD infection increased 1-year mortality (adjusted hazard ratio=5.6; P<0.0001).
conclusionsThis prospective, multicenter study demonstrates that infection frequently complicates VAD placement and is a continuing problem despite the use of newer, smaller devices. Depression and renal dysfunction may increase the risk of VAD infection. VAD infection is a serious consequence because it adversely affects patient survival. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01471795.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.