Evidence map›Paper›PMID 23315322›Full record

ArticleThe Journal of infectious diseases2013

Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.

Mary S Campbell, Erin M Kahle, Connie Celum, Jairam R Lingappa, Saidi Kapiga, Andrew Mujugira, Nelly R Mugo, Kenneth H Fife, James I Mullins, Jared M Baeten and 1 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Per-pathogen virulence of HIV-1 subtypes A, C and D.Proceedings. Biological sciences · 2023
    Article
  5. Article
  6. Article
  7. Acute HIV-1 Infection in Adults in East Africa and Thailand.The New England journal of medicine · 2016
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Reply to Neogi et al.The Journal of infectious diseases · 2013
    Article
  13. Future of phylogeny in HIV prevention.Journal of acquired immune deficiency syndromes (1999) · 2013
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mary S CampbellDepartment of Medicine, University of Washington, Seattle, WA 98195, USA. msc6@u.washington.edu
Erin M Kahle
Connie Celum
Jairam R Lingappa
Saidi Kapiga
Andrew Mujugira
Nelly R Mugo
Kenneth H Fife
James I Mullins
Jared M Baeten
Partners in Prevention HSV/HIV Transmission Study Team

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
Viral Determinants of HIV-1 Transmission in African HeterosexualsP01AI057005 · NIAID · UNIVERSITY OF WASHINGTON · PI MULLINS, JAMES IVAN · 2003 to 2014
$20.5M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Mucosal Transmission and Localized Superinfection in HIV-1K08AI074424 · NIAID · UNIVERSITY OF WASHINGTON · PI CAMPBELL, MARY S · 2007 to 2011
$603k
Medical Research Council G0901756NIAID NIH HHS K08 AI074424NIAID NIH HHS P01 AI057005NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI27757NICHD NIH HHS K24 HD054314PHS HHS P01 057005
6 · The paper itself

Abstract

Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.

Indexed as

Viral LoadAdultAfrica, EasternBlack PeopleDisease Transmission, Infectiousenv Gene Products, Human Immunodeficiency VirusFemalegag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHIV SeropositivityHumansMaleMiddle AgedProspective StudiesRNA, Viralenv Gene Products, Human Immunodeficiency Virusgag Gene Products, Human Immunodeficiency VirusRNA, Viral

Identifiers

PMID23315322
PMCPMC3583276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.