ArticleJournal of assisted reproduction and genetics2013
A closed system supports the developmental competence of human embryos after vitrification : Closed vitrification of human embryos.
Article in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes.Reproductive biology and endocrinology : RB&E · 2018Pooled it
- A novel embryo quality scoring system to compare groups of embryos at different developmental stages.Journal of assisted reproduction and genetics · 2021Article
- Closed vitrification of human oocytes and blastocysts: outcomes from a series of clinical cases.Journal of assisted reproduction and genetics · 2016Article
- Effects of various freezing containers for vitrification freezing on mouse oogenesis.Journal of animal science and technology · 2016Article
- Neonatal outcomes after the implantation of human embryos vitrified using a closed-system device.Journal of assisted reproduction and genetics · 2015Article
- Survival, re-expansion and cell survival of human blastocysts following vitrification and warming using two vitrification systems.Journal of assisted reproduction and genetics · 2015Article
- Cryopreservation in ART and concerns with contamination during cryobanking.Reproductive medicine and biology · 2014Review
- The new Rapid-i carrier is an effective system for human embryo vitrification at both the blastocyst and cleavage stage.Reproductive biology and endocrinology : RB&E · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClosed-system vitrification may enable the risk of contamination to be minimised. We performed three studies to compare the developmental competence of human embryos vitrified using either a closed vitrification system (CVS; Rapid-i®) or an open vitrification system (OVS; Cryo-top®).
methodsThe first study was performed in vitro using 66 zygotes previously vitrified at pronuclear stage. These were warmed and randomised 1:1 to revitrification using either the OVS or the CVS. After re-warming, embryo development and blastocyst cell number were assessed. For the second study, also performed in vitro, 60 vitrified-warmed blastocysts were randomised 1:1:1 into three groups (OVS or CVS revitrification, or no revitrification). The proportion of dead cells was assessed by staining. The third study was performed in vivo, using 263 high-grade blastocysts randomly assigned to vitrification using either the CVS (n = 100) or the OVS (n = 163). After warming, single blastocyst transfer was performed.
resultsThere were no differences between the CVS and the OVS in survival rate (100 % vs. 97 %), blastulation rate (96 h: 50 % vs. 50 %; 120 h: 68 % vs. 56 %), proportion of good blastocysts (96 h: 32 % vs. 22 %, 120 h: 47 % vs. 41 %), or mean number of cells (137 vs. 138). The proportion of dead cells in blastocysts re-vitrified by CVS (31 %) was similar to that for OVS (38 %) and non-revitrification (32 %). In vivo, the implantation rate for blastocysts vitrified using the CVS (54 %) was similar to that with the OVS (53 %).
conclusionOur studies consistently indicate that human embryos may be vitrified using a CVS without impairment of developmental competence.
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