ArticleAmino acids2013
Acute alcohol exposure, acidemia or glutamine administration impacts amino acid homeostasis in ovine maternal and fetal plasma.
Article in Amino acids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- From farm to lab: gene-edited sheep transforming bone research.JBMR plus · 2026Review
- Nonconceptus Mechanisms of Prenatal Alcohol Exposure That Disrupt Embryo-Fetal Development: An Integrative View.Alcohol research : current reviews · 2025Review
- Metabolism and Nutrition of L-Glutamate and L-Glutamine in Ruminants.Animals : an open access journal from MDPI · 2024Review
- Article
- Effects of nutrition and gestational alcohol consumption on fetal growth and development.Nutrition reviews · 2022Review
- Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder.Alcohol (Fayetteville, N.Y.) · 2020Article
- Maternal choline supplementation mitigates alcohol-induced fetal cranio-facial abnormalities detected using an ultrasonographic examination in a sheep model.Alcohol (Fayetteville, N.Y.) · 2019Article
- Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment.Toxicology and applied pharmacology · 2019Review
- Regional dysregulation of taurine and related amino acids in the fetal rat brain following gestational alcohol exposure.Alcohol (Fayetteville, N.Y.) · 2018Article
- Video-based data acquisition system for use in eye blink classical conditioning procedures in sheep.Behavior research methods · 2017Article
- Fetal Alcohol Exposure: The Common Toll.Journal of alcoholism and drug dependence · 2017Article
- Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response.Alcohol (Fayetteville, N.Y.) · 2016Article
- Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs.Alcohol (Fayetteville, N.Y.) · 2016Article
- Observational
- Computed tomography assessment of peripubertal craniofacial morphology in a sheep model of binge alcohol drinking in the first trimester.Alcohol (Fayetteville, N.Y.) · 2015Article
- Formate metabolism in fetal and neonatal sheep.American journal of physiology. Endocrinology and metabolism · 2015Article
- Effects of all three trimester moderate binge alcohol exposure on the foetal hippocampal formation and olfactory bulb.Brain injury · 2015Article
- Effects of L-glutamine supplementation on maternal and fetal hemodynamics in gestating ewes exposed to alcohol.Amino acids · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Fetal alcohol syndrome (FAS) is a significant problem in human reproductive medicine. Maternal alcohol administration alters maternal amino acid homeostasis and results in acidemia in both mother and fetus, causing fetal growth restriction. We hypothesized that administration of glutamine, which increases renal ammoniagenesis to regulate acid-base balance, may provide an intervention strategy. This hypothesis was tested using sheep as an animal model. On day 115 of gestation, ewes were anesthetized and aseptic surgery was performed to insert catheters into the fetal abdominal aorta as well as the maternal abdominal aorta and vena cava. On day 128 of gestation, ewes received intravenous administration of saline, alcohol [1.75 g/kg body weight (BW)/h], a bolus of 30 mg glutamine/kg BW, alcohol + a bolus of 30 mg glutamine/kg BW, a bolus of 100 mg glutamine/kg BW, alcohol + a bolus of 100 mg glutamine/kg BW, or received CO2 administration to induce acidemia independent of alcohol. Blood samples were obtained simultaneously from the mother and the fetus at times 0 and 60 min (the time of peak blood alcohol concentration) of the study. Administration of alcohol to pregnant ewes led to a reduction in concentrations of glutamine and related amino acids in plasma by 21-30%. An acute administration of glutamine to ewes, concurrent with alcohol administration, improved the profile of most amino acids (including citrulline and arginine) in maternal and fetal plasma. We suggest that glutamine may have a protective effect against alcohol-induced metabolic disorders and FAS in the ovine model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.