ArticleJournal of molecular neuroscience : MN2013
The expression changes of cystathionine-β-synthase in brain cortex after traumatic brain injury.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.Critical care medicine · 2018Trial
- Sodium hydrogen sulfide restores HInflammopharmacology · 2025Article
- Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- The Effect of Targeted Hyperoxemia on Brain Immunohistochemistry after Long-Term, Resuscitated Porcine Acute Subdural Hematoma and Hemorrhagic Shock.International journal of molecular sciences · 2024Article
- Post-Traumatic Expressions of Aromatase B, Glutamine Synthetase, and Cystathionine-Beta-Synthase in the Cerebellum of Juvenile Chum Salmon,International journal of molecular sciences · 2024Article
- Intracerebroventricular injection taurine changes free amino acid concentrations in the brain and plasma in chicks.Amino acids · 2023Article
- Epigenetic Modifications and Their Potential Contribution to Traumatic Brain Injury Pathobiology and Outcome.Journal of neurotrauma · 2022Review
- Biological Effects of Hydrogen Sulfide and Its Protective Role in Intracerebral Hemorrhage.Journal of molecular neuroscience : MN · 2020Review
- Review
- Biologic Effect of Hydrogen Sulfide and Its Role in Traumatic Brain Injury.Oxidative medicine and cellular longevity · 2020Review
- Independent impact of plasma homocysteine levels on neurological outcome following head injury.Neurosurgical review · 2018Article
- Neuroprotective effects of hydrogen sulfide on sodium azide‑induced autophagic cell death in PC12 cells.Molecular medicine reports · 2017Article
- Upregulation of 3-MST Relates to Neuronal Autophagy After Traumatic Brain Injury in Mice.Cellular and molecular neurobiology · 2017Article
- Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus.Cellular and molecular neurobiology · 2015Article
- Hydrogen sulfide offers neuroprotection on traumatic brain injury in parallel with reduced apoptosis and autophagy in mice.PloS one · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cystathionine-β-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. It was reported that CBS was a novel marker of both differentiation and proliferation for certain cell types, suggesting that CBS represents a survival-promoting protein. However, its expression and function in the central nervous system lesion are not well understood. To investigate changes of CBS after traumatic brain injury (TBI) and its possible role, mice TBI model was established by controlled cortical impact system, and the expression and cellular localization of CBS after TBI was investigated in the present study. Western blot analysis revealed that CBS was present in normal mice brain cortex. It gradually decreased, reached a valley at the third day after TBI, and then restored to basal level. Importantly, more CBS was colocalized with neuron. In addition, Western blot detection showed that the third day postinjury was also the apoptosis peak indicated by the elevated expression of caspase-3. Importantly, immunohistochemistry analysis revealed that injury-induced expression of CBS was colabeled by Bcl-2 and had no co-localization with caspase-3. These data suggested that CBS may be implicated in the apoptosis of neuron and involved in the pathophysiology of brain after TBI.
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