ArticleChemical senses2013
Weaker ligands can dominate an odor blend due to syntopic interactions.
Article in Chemical senses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Locusts employ neuronal sensory prioritization to reconcile two conflicting olfactory signals while aggregating.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Understanding responses to chemical mixtures: looking forward from the past.Chemical senses · 2022Article
- Effects of Multi-Component Backgrounds of Volatile Plant Compounds on Moth Pheromone Perception.Insects · 2021Article
- Odor coding in the mammalian olfactory epithelium.Cell and tissue research · 2021Review
- Mixture and concentration effects on odorant receptor response patterns in vivo.Chemical senses · 2020Article
- Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.Molecular and cellular neurosciences · 2020Article
- Beverage and Food Fragrance Biotechnology, Novel Applications, Sensory and Sensor Techniques: An Overview.Foods (Basel, Switzerland) · 2019Review
- Article
- Odorant mixtures elicit less variable and faster responses than pure odorants.PLoS computational biology · 2018Article
- Normalizing brain activity across individuals using functional reference mapping.Scientific reports · 2017Article
- Take time: odor coding capacity across sensory neurons increases over time in Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Behavioral Evidence for Enhanced Processing of the Minor Component of Binary Odor Mixtures in LarvalFrontiers in psychology · 2017Article
- A herbivore-induced plant volatile interferes with host plant and mate location in moths through suppression of olfactory signalling pathways.BMC biology · 2015Article
- Characterizing olfactory binary mixture interactions in Fischer 344 rats using behavioral reaction times.Chemical senses · 2015Article
- Odourant dominance in olfactory mixture processing: what makes a strong odourant?Proceedings. Biological sciences · 2015Article
- The scent of mixtures: rules of odour processing in ants.Scientific reports · 2015Article
- Olfactory coding in the insect brain: data and conjectures.The European journal of neuroscience · 2014Review
- More than apples and oranges--detecting cancer with a fruit fly's antenna.Scientific reports · 2014Article
- Article
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4 authors.
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Abstract
Most odors in natural environments are mixtures of several compounds. Perceptually, these can blend into a new "perfume," or some components may dominate as elements of the mixture. In order to understand such mixture interactions, it is necessary to study the events at the olfactory periphery, down to the level of single-odorant receptor cells. Does a strong ligand present at a low concentration outweigh the effect of weak ligands present at high concentrations? We used the fruit fly receptor dOr22a and a banana-like odor mixture as a model system. We show that an intermediate ligand at an intermediate concentration alone elicits the neuron's blend response, despite the presence of both weaker ligands at higher concentration, and of better ligands at lower concentration in the mixture. Because all of these components, when given alone, elicited significant responses, this reveals specific mixture processing already at the periphery. By measuring complete dose-response curves we show that these mixture effects can be fully explained by a model of syntopic interaction at a single-receptor binding site. Our data have important implications for how odor mixtures are processed in general, and what preprocessing occurs before the information reaches the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.