ArticleCerebellum (London, England)2013
Friedreich ataxia: dysarthria profile and clinical data.
Article in Cerebellum (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- The Contributions of Pitch, Loudness, and Rate Control to Speech Naturalness in Cerebellar Ataxia.American journal of speech-language pathology · 2024Article
- Perceptual and Acoustic Analysis of Speech in Spinocerebellar ataxia Type 1.Cerebellum (London, England) · 2024Article
- ClearSpeechTogether: a Rater Blinded, Single, Controlled Feasibility Study of Speech Intervention for People with Progressive Ataxia.Cerebellum (London, England) · 2023Article
- Speech Impairment in Cerebellar Ataxia Affects Naturalness More Than Intelligibility.Cerebellum (London, England) · 2023Article
- Auditory neuropathy in mice and humans with Friedreich ataxia.Annals of clinical and translational neurology · 2023Article
- Speech and Nonspeech Parameters in the Clinical Assessment of Dysarthria: A Dimensional Analysis.Brain sciences · 2023Article
- Congenital or Early Developing Neuromuscular Diseases Affecting Feeding, Swallowing and Speech - A Review of the Literature from January 1998 to August 2021.Journal of neuromuscular diseases · 2022Review
- Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.Human molecular genetics · 2021Article
- Feasibility and Acceptability of Lee Silverman Voice Treatment in Progressive Ataxias.Cerebellum (London, England) · 2020Article
- Speech and Language Disorders in Friedreich Ataxia: Highlights on Phenomenology, Assessment, and Therapy.Cerebellum (London, England) · 2020Review
- Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.Cerebellum (London, England) · 2019Article
- Consensus Paper: Neurophysiological Assessments of Ataxias in Daily Practice.Cerebellum (London, England) · 2018Review
- Adult normative values for the PATA Rate Test.Journal of neurology · 2018Article
- Nonspeech Oral Movements and Oral Motor Disorders: A Narrative Review.American journal of speech-language pathology · 2015Review
- Comparing speech characteristics in spinocerebellar ataxias type 3 and type 6 with Friedreich ataxia.Journal of neurology · 2015Article
- Dysphagia and swallowing-related quality of life in Friedreich ataxia.Journal of neurology · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Friedreich ataxia (FRDA) is the most frequent recessive ataxia in the Western world. Dysarthria is a cardinal feature of FRDA, often leading to severe impairments in daily functioning, but its exact characteristics are only poorly understood so far. We performed a comprehensive evaluation of dysarthria severity and the profile of speech motor deficits in 20 patients with a genetic diagnosis of FRDA based on a carefully selected battery of speaking tasks and two widely used paraspeech tasks, i.e., oral diadochokinesis and sustained vowel productions. Perceptual ratings of the speech samples identified respiration, voice quality, voice instability, articulation, and tempo as the most affected speech dimensions. Whereas vocal instability predicted ataxia severity, tempo turned out as a significant correlate of disease duration. Furthermore, articulation predicted the overall intelligibility score as determined by a systematic speech pathology assessment tool. In contrast, neurologists' ratings of intelligibility--a component of the "Scale for the Assessment and Rating of Ataxia"--were found to be related to perceived speech tempo. Obviously, clinicians are more sensitive to slowness of speech than to any other feature of spoken language during dysarthria evaluation. Our results suggest that different components of speech production and trunk/limb motor functions are differentially susceptible to FRDA pathology. Furthermore, evidence emerged that paraspeech tasks do not allow for an adequate scaling of speech deficits in FRDA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.