ArticlePediatric radiology2013
Diagnostic image quality of gadolinium-enhanced T1-weighted MRI with and without fat saturation in children with retinoblastoma.
Article in Pediatric radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Practical guidelines on imaging of retinoblastoma: a 2025 update on behalf of the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group.European radiology · 2026Guideline
- Diagnostic performance of MRI of post-laminar optic nerve invasion detection in retinoblastoma: A systematic review and meta-analysis.Neuroradiology · 2021Pooled it
- Normative measurements of the frontal nerve by magnetic resonance imaging in an Australia cohort.Surgical and radiologic anatomy : SRA · 2025Article
- [Imaging of retinoblastoma : Current state-of-the-art and future prospects].Radiologie (Heidelberg, Germany) · 2022Review
- Guidelines for magnetic resonance imaging in pediatric head and neck pathologies: a multicentre international consensus paper.Neuroradiology · 2022Article
- MRI-based radiomics model can improve the predictive performance of postlaminar optic nerve invasion in retinoblastoma.The British journal of radiology · 2022Article
- [Retinoblastoma].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion?Ocular oncology and pathology · 2017Article
- Blood flow velocity in monocular retinoblastoma assessed by color Doppler.Clinics (Sao Paulo, Brazil) · 2015Article
- High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma: Part 1: MRI vs. histopathology.Neuroradiology · 2015Article
- High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma: Part 2: new vs. old imaging concept.Neuroradiology · 2015Article
- Assessment of early-stage optic nerve invasion in retinoblastoma using high-resolution 1.5 Tesla MRI with surface coils: a multicentre, prospective accuracy study with histopathological correlation.European radiology · 2015Article
- Clinical Significance of Optic Nerve Enhancement on Magnetic Resonance Imaging in Enucleated Retinoblastoma Patients.Ophthalmology. RetinaArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGadolinium-enhanced T1-weighted MRI without fat saturation has been recommended for assessment of retinoblastoma.
objectiveThe purpose of this study was to compare diagnostic image quality without and with fat saturation following gadolinium administration. MATERIALS AND
methodsHigh-resolution gadolinium-enhanced T1-weighted sequences with and without fat saturation performed in children with subsequently histopathologically confirmed retinoblastoma were included. Image analysis (image quality [1 = poor, 2 = moderate, 3 = good], anatomical detail depiction, tumour extension) was performed by two neuroradiologists in consensus. Enhancement was scored and measured. Signal- and contrast-to-noise ratios were calculated. Image-assessed tumour invasiveness was compared to histopathological findings. Paired sample t-test was used for statistical analysis.
resultsThirty-six children (mean age, 19.0 ± 16.8 [SD] months) were included. Image quality and anatomical detail depiction were significantly better without fat saturation (P < 0.001). Tumour enhancement was rated higher with fat saturation (P < 0.001). Fat saturation improved detection of (post-)laminar optic nerve infiltration. Detection of choroidal invasion was improved without fat saturation. Combining both sequences was best in the assessment of tumour extension (sensitivity/specificity for (post-)laminar optic nerve infiltration, 75.0%/100.0%, and for choroidal invasion, 87.5%/85.7%).
conclusionCombined T1-weighted spin-echo imaging with and without fat saturation improved the image quality for assessment of invasiveness of retinoblastoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.