ArticleReproductive sciences (Thousand Oaks, Calif.)2013
Intraamniotic lipopolysaccharide exposure changes cell populations and structure of the ovine fetal thymus.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates.International journal of molecular sciences · 2025Review
- Radiological changes in the thymus in patients who have had COVID-19 and in vaccinated persons who have not had COVID-19: a CT study.Radiologie (Heidelberg, Germany) · 2024Article
- Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging.Prenatal diagnosis · 2022Review
- The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II.ImmunoHorizons · 2021Article
- Role of Infection and Immunity in Bovine Perinatal Mortality: Part 2. Fetomaternal Response to Infection and Novel Diagnostic Perspectives.Animals : an open access journal from MDPI · 2021Review
- Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus.Scientific reports · 2021Article
- Intestinal Goblet Cell Loss during Chorioamnionitis in Fetal Lambs: Mechanistic Insights and Postnatal Implications.International journal of molecular sciences · 2021Article
- Understanding Host-Pathogen Interactions in Acute Chorioamnionitis Through the Use of Animal Models.Frontiers in cellular and infection microbiology · 2021Review
- Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus.Molecular medicine (Cambridge, Mass.) · 2020Article
- The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications.Seminars in fetal & neonatal medicine · 2020Article
- Immunobiology of Acute Chorioamnionitis.Frontiers in immunology · 2020Review
- Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus.Journal of neuroinflammation · 2018Article
- Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica.Scientific reports · 2017Article
- Article
- Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis.Clinical and experimental immunology · 2016Observational
- Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Alterations of Thymic Epithelial Cells in Lipopolysaccharide-induced Neonatal Thymus Involution.Chinese medical journal · 2016Article
- Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.American journal of obstetrics and gynecology · 2015Review
- Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates.Human immunology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
rationaleChorioamnionitis induces preterm delivery and acute involution of the fetal thymus which is associated with postnatal inflammatory disorders. We studied the immune response, cell composition, and architecture of the fetal thymus following intraamniotic lipopolysaccharide (LPS) exposure.
methodsTime-mated ewes received an intraamniotic injection of LPS 5, 12, or 24 hours or 2, 4, 8, or 15 days before delivery at 125 days gestational age (term = 150 days).
resultsThe LPS exposure resulted in decreased blood lymphocytes within 5 hours and decreased thymic corticomedullary ratio within 24 hours. Thymic interleukin 6 (IL6) and IL17 messenger RNA (mRNA) increased 5-fold 24 hours post-LPS exposure. Increased toll-like receptor 4 (TLR4) mRNA and nuclear factor κB positive cells at 24 hours after LPS delivery demonstrated acute thymic activation. Both TLR4 and IL1 mRNA increased by 5-fold and the number of Foxp3-positive cells (Foxp3+ cells) decreased 15 days after exposure.
conclusionIntraamniotic LPS exposure caused a proinflammatory response, involution, and a persistent depletion of thymic Foxp3+ cells indicating disturbance of the fetal immune homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.