ArticleJournal of neuro-oncology2013
Role of surgery, radiotherapy and chemotherapy in papillary tumors of the pineal region: a multicenter study.
Article in Journal of neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Surgical management of pineal region tumors in Italy: a SINch (SINch®) National Survey with systematic review.Neurosurgical review · 2026Pooled it
- Papillary Tumors of the Pineal Region (PTPR) in Pediatric Population: A Case Report and Literature Review.Asia-Pacific journal of clinical oncology · 2026Review
- Article
- Fractionated Gamma Knife Radiation for Papillary Tumor of the Pineal Region: A Case Report and Literature Review.Clinical case reports · 2026Article
- Decisional Tree for Pineal Tumors.Advances and technical standards in neurosurgery · 2026Review
- Pineal Tumors and Pineal Region Tumors.Advances and technical standards in neurosurgery · 2026Review
- Histopathology and Molecular Pathology of Pineal Region Tumors.Advances and technical standards in neurosurgery · 2026Review
- Adjuvant radiotherapy for papillary tumor of the pineal region: a case report with a narrative review of the literature.International cancer conference journal · 2025Article
- Papillary Tumor of the Pineal Region Treated With Surgery and Postoperative Radiotherapy: A Case Report.Cureus · 2025Article
- Two illustrative cases of papillary tumor of the pineal region: Clinical presentation, management, and outcomes.Surgical neurology international · 2025Article
- SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors.Neuro-oncology · 2024Review
- Determination of Optimal Treatment Plan for Papillary Tumor of the Pineal Region: Case Series With Literature Review.Brain tumor research and treatment · 2024Article
- Histopathology and molecular pathology of pediatric pineal parenchymal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Benign and Malignant Tumors of the Pineal Region.Advances in experimental medicine and biology · 2023Article
- Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC).Current oncology (Toronto, Ont.) · 2022Article
- Papillary tumor of the pineal region in pediatric patient - A case report.Surgical neurology international · 2022Article
- Papillary tumor of the pineal region: Is stereotactic radiosurgery efficient for this rare entity?Surgical neurology international · 2021Article
- Papillary tumor of the pineal region: a single-center experience.Neuro-oncology practice · 2020Article
- Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.Neuro-oncology · 2017Article
- Papillary tumor of the pineal region with extended clinical and radiologic follow-up.Surgical neurology international · 2015Article
Corrections and comments
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Authors and funding
13 authors at 11 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papillary tumor of the pineal region (PTPR), recently described as a distinct clinicopathological entity, can show aggressive biological behavior. The optimal therapeutic approach of PTPR has not been well defined. The role of surgery, radiotherapy, and chemotherapy in the treatment of PTPR was analyzed in a large multicenter series. In order to determine factors that influence prognosis, outcome data of a series of 44 patients with histopathologically proven PTPR were retrospectively analyzed. Of the 44 patients, 32 were still alive after a median follow-up of 63.1 months. Twelve patients experienced progressive disease, with seven undergoing two relapses and five more than two. Median overall survival (OS) was not achieved. Median progression-free survival (PFS) was 58.1 months. Only gross total resection and younger age were associated with a longer OS, radiotherapy and chemotherapy having no significant impact. PFS was not influenced by gross total resection. Radiotherapy and chemotherapy had no significant effect. This retrospective series confirms the high risk of recurrence in PTPR and emphasizes the importance of gross total resection. However, our data provide no evidence for a role of adjuvant radiotherapy or chemotherapy in the treatment of PTPR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.