ArticleHistochemistry and cell biology2013
Immunohistochemical characteristics of suburothelial microvasculature in the mouse bladder.
Article in Histochemistry and cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Role of ANO1 CaPflugers Archiv : European journal of physiology · 2025Article
- Intramural Blood Vessels as a Primary Site of Vascular LUTS.Lower urinary tract symptoms · 2025Review
- Stress-induced impairment of parasympathetic NO-mediated inhibition of sympathetic vasoconstriction in submucosal arteriole of rat rectum.Pflugers Archiv : European journal of physiology · 2024Article
- Functional nitrergic innervation of smooth muscle structures in the mucosa of pig lower urinary tract.Cell and tissue research · 2021Article
- Three-Dimensional Reconstruction of Neurovascular Network in Whole Mount Preparations and Thick-Cut Transverse Sections of Mouse Urinary Bladder.The world journal of men's health · 2021Article
- Excitability and contractility in arterioles and venules from the urinary bladder.Current topics in membranes · 2020Review
- Synchrony of spontaneous CaJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Review
- Role of capillary pericytes in the integration of spontaneous CaThe Journal of physiology · 2018Article
- Properties of synchronous spontaneous CaPflugers Archiv : European journal of physiology · 2017Article
- Contractile properties of periosteal arterioles in the guinea-pig tibia.Pflugers Archiv : European journal of physiology · 2017Article
- Inhibition of vascular smooth muscle inward-rectifier KAmerican journal of physiology. Renal physiology · 2017Article
- The link between vascular dysfunction, bladder ischemia, and aging bladder dysfunction.Therapeutic advances in urology · 2017Review
- Spontaneous activity in the microvasculature of visceral organs: role of pericytes and voltage-dependent Ca(2+) channels.The Journal of physiology · 2016Review
- Mechanisms underlying spontaneous constrictions of postcapillary venules in the rat stomach.Pflugers Archiv : European journal of physiology · 2016Article
- Functional properties of submucosal venules in the rat stomach.Pflugers Archiv : European journal of physiology · 2015Article
- The Histochem Cell Biol conspectus: the year 2013 in review.Histochemistry and cell biology · 2014Review
- Properties of submucosal venules in the rat distal colon.British journal of pharmacology · 2013Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morphological characteristics of smooth muscle cells (SMCs) and their innervation of the suburothelial microvasculature of the mouse bladder were investigated by immunohistochemistry. Whole mount bladder mucosal preparations were immune-stained for α-smooth muscle actin (α-SMA) and/or neuronal markers and examined using confocal laser scanning microscopy. Suburothelial arterioles consisted of α-SMA-immunopositive circular smooth muscle cells, while the venular wall composed of α-SMA-positive SMCs that displayed several processes which extended from their cell bodies to form an extensive meshwork. In larger venules, a complex meshwork of stellate-shaped SMCs were observed. NG2 chondroitin sulphate proteoglycan-immunoreactive cell bodies of capillary pericytes were not immunoreactive for α-SMA. In the rat bladder suburothelial venules, circular SMCs were the dominant cell type expressing α-SMA-immunoreactivity. Since α-SMA-positive SMCs in suburothelial arterioles and venules in the mouse bladder had quite distinct morphologies, the innervation of both vessels could be examined by double labelling for α-SMA and various neuronal markers. Varicose nerve bundles immunoreactive for tyrosine hydroxylase (sympathetic nerves), choline acetyltransferase (cholinergic nerves) or substance P (primary afferent nerves) were all detected along side suburothelial arterioles. Single varicose nerve fibres positive for these three neuronal markers were also detected around the venules. Thus, whole mount preparations are useful when examining the morphology of α-SMA-positive SMCs of the microvasculature in the suburothelium of mouse bladder as well as their relationship with their innervations. In conclusion, arterioles and venules of the bladder suburothelium are the target of sympathetic, cholinergic and primary afferent nerve fibres.
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