Trial reportPediatric nephrology (Berlin, Germany)2013
Prospective 5-year follow-up of cyclosporine treatment in children with steroid-resistant nephrosis.
Trial report in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: medical therapy.Clinical and experimental nephrology · 2015Guideline
- Rituximab-induced long-term remission in childhood-onset, uncomplicated, frequently relapsing or steroid-dependent nephrotic syndrome: a randomized, placebo-controlled trial and a follow-up study.Scientific reports · 2025Trial
- Trial
- [Efficacy and safety of rituximab in children with refractory nephrotic syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial.JAMA pediatrics · 2025Article
- Adult survivors of childhood-onset steroid-dependent and steroid-resistant nephrotic syndrome treated with cyclosporine: a long-term single-center experience.Pediatric nephrology (Berlin, Germany) · 2024Article
- Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
- Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience.Singapore medical journal · 2020Article
- Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients.Kidney research and clinical practice · 2018Article
- Rituximab in steroid-sensitive nephrotic syndrome: lessons from clinical trials.Pediatric nephrology (Berlin, Germany) · 2018Review
- Acute kidney injury in idiopathic nephrotic syndrome of childhood is a major risk factor for the development of chronic kidney disease.Renal failure · 2017Article
- High incidence of idiopathic nephrotic syndrome in East Asian children: a nationwide survey in Japan (JP-SHINE study).Clinical and experimental nephrology · 2017Article
- Variability of diagnostic criteria and treatment of idiopathic nephrotic syndrome across European countries.European journal of pediatrics · 2017Article
- Long-term outcome of idiopathic steroid-resistant nephrotic syndrome in children.Pediatric nephrology (Berlin, Germany) · 2016Article
- Favorable outcome in children with idiopathic steroid-resistant nephrotic syndrome due to mesangial hypercellularity: A distinct disease entity?Pediatric nephrology (Berlin, Germany) · 2016Article
- Rapid Response to Cyclosporin A and Favorable Renal Outcome in Nongenetic Versus Genetic Steroid-Resistant Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2016Article
- AKI in Children Hospitalized with Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Response to cyclosporine in steroid-resistant nephrotic syndrome: discontinuation is possible.Pediatric nephrology (Berlin, Germany) · 2015Article
- Spectrum of steroid-resistant and congenital nephrotic syndrome in children: the PodoNet registry cohort.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Long-Term Outcomes in Children with Steroid-Resistant Nephrotic Syndrome Treated with Calcineurin Inhibitors.Frontiers in pediatrics · 2015Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclosporine has improved remission rates in children with steroid-resistant nephrotic syndrome (SRNS). However, little prospective long-term follow-up data is available.
methodsWe prospectively followed and analyzed 5-year outcomes of all 35 patients enrolled in our previous prospective multicenter trial with cyclosporine and steroids in children with SRNS. At enrollment, 23 cases were classified as minimal change (MC), five as diffuse mesangial proliferation (DMP), and seven as focal segmental glomerulosclerosis (FSGS).
resultsRenal survival at 5 years (median 7.7 years) was 94.3 %. Patient status was complete remission (CR) in 31 (88.6 %) (MC/DMP, 25; FSGS, 6); partial remission in one (FSGS); and non-remission in three (MC/DMP), including chronic kidney disease and end-stage kidney disease in one each. Among 31 patients with CR, 22 (71.0 %) were receiving treatment with immunosuppressants at 5 years, including cyclosporine in 19, and seven of these 22 continued to show frequent relapse. Response to cyclosporine at 4 months predicted 5-year outcome in 31 of 35 patients.
conclusionsAlthough SRNS treatment with cyclosporine provides high renal survival and remission rates, many children require ongoing immunosuppression. Management has advanced from the prevention of end-stage kidney disease to the long-term maintenance of remission and management of relapse after induction therapy.
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