Trial reportJournal of acquired immune deficiency syndromes (1999)2013
A randomized trial of Mogen clamp versus Plastibell for neonatal male circumcision in Botswana.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Plastic Clamp Versus Conventional Surgical Dissection Technique in Pediatric Circumcision: A Systematic Review and Meta-Analysis.Current urology reports · 2024Pooled it
- Challenges of management and outcome of neonatal surgery in Africa: a systematic review.Pediatric surgery international · 2016Pooled it
- Factors associated with parental non-adoption of infant male circumcision for HIV prevention in Sub-Saharan Africa: a systematic review and thematic synthesis.AIDS and behavior · 2014Pooled it
- ShangRing versus Mogen clamp for early infant male circumcision in eastern sub-Saharan Africa: a multicentre, non-inferiority, adaptive, randomised controlled trial.The Lancet. Global health · 2022Trial
- Estimating the Cost of Early Infant Male Circumcision in Zimbabwe: Results From a Randomized Noninferiority Trial of AccuCirc Device Versus Mogen Clamp.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Implementation and Operational Research: A Randomized Noninferiority Trial of AccuCirc Device Versus Mogen Clamp for Early Infant Male Circumcision in Zimbabwe.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Single-arm evaluation of the AccuCirc device for early infant male circumcision in Botswana.Journal of acquired immune deficiency syndromes (1999) · 2014Trial
- Can combination prevention strategies reduce HIV transmission in generalized epidemic settings in Africa? The HPTN 071 (PopART) study plan in South Africa and Zambia.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- Successful Penile Replantation Following Amputation During Neonatal Circumcision: Case Report and Systematic Review.Plastic and reconstructive surgery. Global open · 2026Article
- Health worker perspectives on, and health system-level facilitators and barriers to early infant male circumcision for HIV prevention in a traditionally non-circumcising community, Northeastern Uganda: a cross-sectional qualitative study.BMC health services research · 2025Article
- Comparison of a modified Mogen clamp and classic dorsal slit circumcision under local anesthesia: A clinical study.Current urology · 2022Article
- Healthcare providers' perceptions and understanding of voluntary medical male circumcision in KwaZulu-Natal, South Africa: A qualitative study.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2021Article
- Assessment of risk factors for surgical complications in neonatal circumcision clinic.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2019Article
- Field evaluation of the safety, acceptability, and feasibility of early infant male circumcision using the AccuCirc device.PloS one · 2018Article
- Unpacking early infant male circumcision decision-making using qualitative findings from Zimbabwe.BMC international health and human rights · 2017Article
- Article
- Reported Male Circumcision Practices in a Muslim-Majority Setting.BioMed research international · 2017Article
- Acceptability and feasibility of early infant male circumcision for HIV prevention in Malawi.PloS one · 2017Article
- Factors Associated with Preference for Early Infant Male Circumcision Among a Representative Sample of Parents in Homa Bay County, Western Kenya.AIDS and behavior · 2016Article
- Perspectives of Parents and Health Care Workers on Early Infant Male Circumcision Conducted Using Devices: Qualitative Findings From Harare, Zimbabwe.Global health, science and practice · 2016Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMale circumcision can reduce the risk of heterosexually acquired HIV-1 infection in men. Neonatal male circumcision (NMC) has many potential advantages over circumcision at older ages, but little is known about its feasibility and safety in resource-limited settings.
methodsWe performed a randomized trial in southeastern Botswana of Mogen clamp and Plastibell, 2 commonly used devices for NMC. Follow-up visits occurred at 6 weeks and 4 months postpartum. Adverse events, parental satisfaction, and staff impressions were recorded.
resultsOf 302 male neonates randomized, 300 (99%) underwent circumcision, 153 (51%) with Mogen clamp, and 147 (49%) with Plastibell. There were no major adverse events in the Mogen clamp arm, but there were 2 major adverse events in the Plastibell arm (both were a proximally migrated ring that had to be removed by study staff). Minor adverse events were more common with the Mogen clamp compared with the Plastibell, specifically removal of too little skin and formation of skin bridges or adhesions (12 versus 1 and 11 versus 3, respectively, all P < 0.05). Five (3%) infants in the Mogen clamp arm and none in the Plastibell arm had minor bleeding (P = 0.03). More than 94% of mothers reported being highly or completely satisfied with the procedure.
conclusionsNMC can be performed in Botswana with a low rate of adverse events and high parental satisfaction. Although the risk of migration and retention of the Plastibell is small, the Mogen clamp may be safer for NMC in regions where immediate emergent medical attention is not available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.