Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Naloxone-reversible modulation of pain circuitry by left prefrontal rTMS.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03984201 (Accelerated Theta Burst in Chronic Pain), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated Theta Burst in Chronic Pain: A Biomarker Study
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020Pooled it
- Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Endogenous opioid antagonism in physiological experimental pain models: a systematic review.PloS one · 2015Pooled it
- Combining Pulsed Radiofrequency With Transcranial Magnetic Stimulation to Manage Hemiplegic Shoulder Pain and Somatosensory Nerve Transmissions.Pain research & management · 2026Trial
- Analgesic effects of high-frequency rTMS on pain anticipation and perception.Communications biology · 2024Trial
- The role of endogenous opioids in mindfulness and sham mindfulness-meditation for the direct alleviation of evoked chronic low back pain: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Exploring HD-tDCS Effect on μ-opioid Receptor and Pain Sensitivity in Temporomandibular Disorder: A Pilot Randomized Clinical Trial Study.The journal of pain · 2024Trial
- Prolonged continuous theta burst stimulation increases motor corticospinal excitability and intracortical inhibition in patients with neuropathic pain: An exploratory, single-blinded, randomized controlled trial.Neurophysiologie clinique = Clinical neurophysiology · 2023Trial
- Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism.Molecular psychiatry · 2019Trial
- Correlation of Pain Reduction with fMRI BOLD Response in Osteoarthritis Patients Treated with Paracetamol: Randomized, Double-Blind, Crossover Clinical Efficacy Study.Pain medicine (Malden, Mass.) · 2018Trial
- Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
- Transcranial magnetic stimulation in the treatment of chronic widespread pain: a randomized controlled study.The journal of ECT · 2015Trial
- Building up analgesia in humans via the endogenous μ-opioid system by combining placebo and active tDCS: a preliminary report.PloS one · 2014Trial
- Trial
- The Effectiveness of Transcranial Direct Current Stimulation (tDCS) in Improving Performance in Soccer Players-A Scoping Review.Journal of clinical medicine · 2026Review
- Effect of Repetitive Transcranial Magnetic Stimulation on the Symptoms and Brain Imaging in Patients with Fibromyalgia Syndrome: A Randomized Controlled Pilot Trial.Pain and therapy · 2025Article
- The Use of Non-Invasive Brain Stimulation for the Management of Chronic Musculoskeletal Pain: Fad or Future?Brain sciences · 2025Article
- Neural circuits controlling choice behavior in opioid addiction.Neuropharmacology · 2023Review
- A randomised sham-controlled study evaluating rTMS analgesic efficacy for postherpetic neuralgia.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A 20-minute session of 10 Hz repetitive transcranial magnetic stimulation (rTMS) of Brodmann Area (BA) nine of the left dorsolateral prefrontal cortex (DLPFC) can produce analgesic effects on postoperative and laboratory-induced pain. This analgesia is blocked by pretreatment with naloxone, a μ-opioid antagonist. The purpose of this sham-controlled, double-blind, crossover study was to identify the neural circuitry that underlies the analgesic effects of left DLPFC rTMS, and to examine how the function of this circuit, including midbrain and medulla, changes during opioid blockade. Fourteen healthy volunteers were randomized to receive intravenous saline or naloxone immediately before sham and real left DLPFC rTMS on the same experimental visit. One week later, each participant received the novel pretreatment but the same stimulation paradigm. Using short sessions of heat on capsaicin-sensitized skin, hot allodynia was assessed during 3 Tesla functional magnetic resonance imaging (fMRI) scanning at baseline, post-sham rTMS, and post-real rTMS. Data were analyzed using whole-brain voxel-based analysis, as well as time series extractions from anatomically-defined regions of interest representing midbrain and medulla. Consistent with previous findings, real rTMS significantly reduced hot allodynia pain ratings. This analgesia was associated with elevated blood oxygenation-level dependent (BOLD) signal in BAs 9 and 10, and diminished BOLD signal in the anterior cingulate, thalamus, midbrain, and medulla during pain. Naloxone pretreatment largely abolished rTMS-induced analgesia, as well as rTMS-induced attenuation of BOLD signal response to painful stimuli throughout pain processing regions, including midbrain and medulla. These preliminary results suggest that left DLPFC rTMS drives top-down opioidergic analgesia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.