ArticleAnnals of plastic surgery2014
Quantification and characterization of radiation-induced changes to mandibular vascularity using micro-computed tomography.
Article in Annals of plastic surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Post head and neck cancer radiation therapy dynamic contrast enhanced magnetic resonance imaging association with high mandibular radiation dose.medRxiv : the preprint server for health sciences · 2025Article
- Pain hypersensitivity, sensorimotor impairment, and decreased muscle force in a novel rat model of radiation-induced peripheral neuropathy.Journal of the peripheral nervous system : JPNS · 2024Article
- The mechanism of bone metabolism in a Sprague Dawley rat model of mandibular osteoradionecrosis.Quantitative imaging in medicine and surgery · 2024Article
- Dual-energy CT for the detection of skull base invasion in nasopharyngeal carcinoma: comparison of simulated single-energy CT and MRI.Insights into imaging · 2023Article
- Overcoming Nuclear Winter: The Cutting-edge Science of Bone Healing and Regeneration in Irradiated Fields.Plastic and reconstructive surgery. Global open · 2021Article
- Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy.Journal of neuro-oncology · 2021Article
- Dental implants rehabilitation in a patient with head and neck radiotherapy for osteosarcoma in the jaw. A clinical case report.Journal of clinical and experimental dentistry · 2021Article
- In vivo quantification of mandibular bone remodeling and vascular changes in a Wistar rat model: A novel HR-MRI and micro-CT fusion technique.Imaging science in dentistry · 2020Article
- New methods for objective angiogenesis evaluation of rat nerves using microcomputed tomography scanning and conventional photography.Microsurgery · 2020Article
- Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization.NPJ Regenerative medicine · 2019Article
- Development of an experimental model for radiation-induced inhibition of cranial bone regeneration.Maxillofacial plastic and reconstructive surgery · 2018Article
- Dual-Energy CT in Head and Neck Imaging.Current radiology reports · 2017Review
- Changes in Skin Vascularity in a Murine Model for Postmastectomy Radiation.Annals of plastic surgery · 2016Article
- Stem cells rejuvenate radiation-impaired vasculogenesis in murine distraction osteogenesis.Plastic and reconstructive surgery · 2015Article
- Prophylactic administration of Amifostine protects vessel thickness in the setting of irradiated bone.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2015Article
- Deferoxamine administration delivers translational optimization of distraction osteogenesis in the irradiated mandible.Plastic and reconstructive surgery · 2013Article
- Deferoxamine restores callus size, mineralization, and mechanical strength in fracture healing after radiotherapy.Plastic and reconstructive surgery · 2013Article
- Article
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6 authors at 1 institution in 2 countries.
Funding
Abstract
objectivePerhaps the most vexing and exigent problem confronting head and neck cancer reconstruction is overcoming the impediments of collateral damage imposed by radiation therapy (XRT) on normal surrounding tissue. Radiation therapy is detrimental to bone and soft tissue repair resulting in an unacceptably high incidence of devastating wound healing complications as well as the associated morbidity of late pathologic fractures, reduced bone healing, and osteoradionecrosis. The consequences of XRT on bone vasculature, long known to be affected by radiation, have been poorly understood. The purpose of this study was to analyze the degree by which irradiation degrades existing bone vascularity using a powerful micro-computed tomography technique to attain highly precise quantitative metrics of the vascular tree.
methodsFourteen 400-g male Sprague-Dawley rats underwent 35 Gy of fractionated XRT at 7 Gy/d. The animals were euthanized after 28 days, and the left ventricle was fixed and injected with Microfil (MV-122; Flow Tech, Carver, Mass) contrast. Left hemimandibles were dissected and scanned using high-resolution micro-computed tomography (18-μm voxels). The vessel number, thickness, separation, connectivity, and vessel volume fraction were analyzed for the region of interest, defined to be the volume behind the third molar spanning a total distance of 5.1 mm.
resultsStereologic analysis and subsequent analysis of variance test demonstrated a significant and quantifiable diminution in the irradiated vasculature when compared with control animals. The vessel volume fraction (0.016 vs 0.032, P ≤ 0.003) and vessel thickness (0.042 vs 0.067 mm, P ≤ 0.001) were markedly reduced. Interestingly, further analysis demonstrated no significant differences between vessel separation and vessel number.
conclusionsThe results of our study specifically quantify the corrosive affects of XRT on the vasculature of the mandible. The data from this novel technique go even further and imply retention of blood vessels but a degradation of their quality and size. Further experiments can now be directed at therapeutic interventions to reverse this process and better understand the underlying mechanism of XRT-induced bone injury.
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