Trial reportJournal of substance abuse treatment2013
Gender differences in a clinical trial for prescription opioid dependence.
Trial report in Journal of substance abuse treatment, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
123 citing papers in PubMed, 2 syntheses or guidelines pooled it, 229 citations in OpenAlex.
- Intimate partner violence as a predictor of substance use outcomes among women: A systematic review.Addictive behaviors · 2022Pooled it
- Sex- and Gender-Based Analysis in Cannabis Treatment Outcomes: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Clinical and psychosocial outcomes by sex among individuals prescribed buprenorphine-naloxone (BUP-NX) or extended-release naltrexone (XR-NTX) for opioid use disorder.The American journal on addictions · 2023Trial
- Gender and addiction and other mental disorders comorbidity: sociodemographic, clinical, and treatment differences.Archives of women's mental health · 2023Trial
- Gender differences among criminal justice-involved persons living with HIV interested in extended-release naltrexone treatment.Substance abuse · 2021Trial
- Parallel modeling of pain and depression in prediction of relapse during buprenorphine and naloxone treatment: A finite mixture model.Drug and alcohol dependence · 2020Trial
- Past-year Prescription Drug Monitoring Program Opioid Prescriptions and Self-reported Opioid Use in an Emergency Department Population With Opioid Use Disorder.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2018Trial
- A randomized, controlled trial of the efficacy of an interoceptive exposure-based CBT for treatment-refractory outpatients with opioid dependence.Journal of psychoactive drugsTrial
- Gender Differences in Health Risk Factors for Co-Use of Gabapentin and Opioids among Black Americans.Addiction research & theory · 2026Article
- Age, sex, and ethnic differences in substance use and/or substance use disorders among runaway and homeless youth: A meta-analysis and meta-regression.European child & adolescent psychiatry · 2026Review
- Gender-specific addiction research needed now more than ever: Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group.Journal of substance use and addiction treatment · 2025Article
- Gender differences in opioid and stimulant poisoning in the central region of iran: a cross-sectional study.Scientific reports · 2025Article
- Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains.Biological psychiatry global open science · 2025Article
- Gender differences in circumstances associated with cannabis use.The American journal on addictions · 2025Article
- Outcome of Buprenorphine maintenance treatment among Indian females with opioid dependence: Report from a tertiary addiction treatment center.Indian journal of psychiatry · 2025Article
- Sex Differences in Opioid Misuse among Adults with Chronic Lower Back Pain: The Roles of Negative Affect and Related Transdiagnostic Factors.Journal of substance use · 2025Article
- Contemporaneous Link Between Pain and Craving in Patients Recovering from Prescription Opioid Use Disorder During Residential Treatment.Substance use & misuse · 2025Article
- Racial and sex disparities in inpatient outcomes of patients with opioid overdose: a nationwide analysis.Proceedings (Baylor University. Medical Center) · 2025Article
- A prospective cohort of treatment-seeking patients with problematic use of prescription narcotic drugs: study protocol and baseline characteristics.BMC psychiatry · 2024Observational
- Sex differences in comorbid pain and opioid use disorder: A scoping review.British journal of clinical pharmacology · 2024Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Although gender differences in substance use disorders have been identified, few studies have examined gender differences in prescription drug dependence. The aim of this study was to examine gender differences in clinical characteristics and treatment outcomes in a large clinical trial for prescription opioid dependence. Despite no pre-treatment differences in opioid dependence severity, women reported significantly greater functional impairment, greater psychiatric severity, and higher likelihood of using opioids to cope with negative affect and pain than men. Women were also more likely than men to have first obtained opioids via a legitimate prescription and to use opioids via the intended route of administration. Men reported significantly more alcohol problems than women. There were no significant gender differences in medication dose, treatment retention, or opioid outcomes. Thus, despite the presence of pre-treatment gender differences in this population, once the study treatment was initiated, women and men exhibited similar opioid use outcomes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.