ArticleNeuron2013
Fast silencing reveals a lost role for reciprocal inhibition in locomotion.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.eLife · 2025Article
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.bioRxiv : the preprint server for biology · 2025Article
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- Bursting emerges from the complementary roles of neurons in a four-cell network.Journal of neurophysiology · 2022Article
- An early midbrain sensorimotor pathway is involved in the timely initiation and direction of swimming in the hatchlingFrontiers in neural circuits · 2022Article
- The CPGs for Limbed Locomotion-Facts and Fiction.International journal of molecular sciences · 2021Review
- Behavioral Role of the Reciprocal Inhibition between a Pair of Mauthner Cells during Fast Escapes in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Stimulation of Single, Possible CHX10 Hindbrain Neurons Turns Swimming On and Off in YoungFrontiers in cellular neuroscience · 2019Article
- Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.Current biology : CB · 2018Article
- A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times.The Journal of physiology · 2018Article
- Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning.Redox biology · 2018Article
- Commentary: Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.Frontiers in neural circuits · 2018Article
- Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.Journal of neurophysiology · 2017Review
- Phasic inhibition as a mechanism for generation of rapid respiratory rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Delineating the Diversity of Spinal Interneurons in Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- The modulation of two motor behaviors by persistent sodium currents inJournal of neurophysiology · 2017Article
- Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.Frontiers in neural circuits · 2017Article
- Rhythm generation, coordination, and initiation in the vocal pathways of male African clawed frogs.Journal of neurophysiology · 2017Article
- The central pattern generator underlying swimming in Dendronotus iris: a simple half-center network oscillator with a twist.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Alternating contractions of antagonistic muscle groups during locomotion are generated by spinal "half-center" networks coupled in antiphase by reciprocal inhibition. It is widely thought that reciprocal inhibition only coordinates the activity of these muscles. We have devised two methods to rapidly and selectively silence neurons on just one side of Xenopus tadpole spinal cord and hindbrain, which generate swimming rhythms. Silencing activity on one side led to rapid cessation of activity on the other side. Analyses reveal that this resulted from the depression of reciprocal inhibition connecting the two sides. Although critical neurons in intact tadpoles are capable of pacemaker firing individually, an effect that could support motor rhythms without inhibition, the swimming network itself requires ~23 min to regain rhythmic activity after blocking inhibition pharmacologically, implying some homeostatic changes. We conclude therefore that reciprocal inhibition is critical for the generation of normal locomotor rhythm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.