ArticleNeuron2013
Distinct roles of TRP channels in auditory transduction and amplification in Drosophila.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 164 citations in OpenAlex.
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
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- Somatotopic organization among parallel sensory pathways that promote a grooming sequence inbioRxiv : the preprint server for biology · 2023Article
- Cryo-EM structure of TMEM63C suggests it functions as a monomer.Nature communications · 2023Article
- Organization of an Ascending Circuit that Conveys Flight Motor State.bioRxiv : the preprint server for biology · 2023Article
- The Voltage-Gated Sodium Channel ineNeuro · 2023Article
- Azimuthal invariance to looming stimuli in the Drosophila giant fiber escape circuit.The Journal of experimental biology · 2023Article
- Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction.The Journal of general physiology · 2023Article
- Nociception and hypersensitivity involve distinct neurons and molecular transducers inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nanchung and Inactive define pore properties of the native auditory transduction channel inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Differential effects on neuromuscular physiology betweenmicroPublication biology · 2021Article
- Mechanotransduction channel Piezo is widely expressed in the spider, Cupiennius salei, mechanosensory neurons and central nervous system.Scientific reports · 2021Article
- Axonemal Dynein DNAH5 is Required for Sound Sensation in Drosophila Larvae.Neuroscience bulletin · 2021Article
- Review
- Multisensory interactions regulate feeding behavior inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Auditory activity is diverse and widespread throughout the central brain of Drosophila.Nature neuroscience · 2021Article
- Sub-Ciliary Segregation of TwoMolecules and cells · 2020Article
- Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Auditory receptor cells rely on mechanically gated channels to transform sound stimuli into neural activity. Several TRP channels have been implicated in Drosophila auditory transduction, but mechanistic studies have been hampered by the inability to record subthreshold signals from receptor neurons. Here, we develop a non-invasive method for measuring these signals by recording from a central neuron that is electrically coupled to a genetically defined population of auditory receptor cells. We find that the TRPN family member NompC, which is necessary for the active amplification of sound-evoked motion by the auditory organ, is not required for transduction in auditory receptor cells. Instead, NompC sensitizes the transduction complex to movement and precisely regulates the static forces on the complex. In contrast, the TRPV channels Nanchung and Inactive are required for responses to sound, suggesting they are components of the transduction complex. Thus, transduction and active amplification are genetically separable processes in Drosophila hearing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.