ArticleACS nano2013
Quantitative photoacoustic imaging of nanoparticles in cells and tissues.
Article in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Improved quantification of photoacoustic biomarkers through residual-based noise masking.Photoacoustics · 2026Article
- Nanoparticle Detection in Biology and Medicine: A Review.Biosensors · 2025Review
- Depth-dependent fluence compensation withoutJournal of biomedical optics · 2025Article
- A comprehensive review on nanoparticle-based photo acoustic: current application and future prospective.Discover nano · 2024Review
- Quantifying particle concentrationNanoscale · 2024Article
- Dual-modal Photoacoustic and Ultrasound Imaging: from preclinical to clinical applications.Frontiers in photonics · 2024Article
- Article
- A novel photoacoustic-fluorescent contrast agent for quantitative imaging of lymphatic drainage.Photoacoustics · 2021Article
- Transcranial Photoacoustic Detection of Blood-Brain Barrier Disruption Following Focused Ultrasound-Mediated Nanoparticle Delivery.Molecular imaging and biology · 2020Article
- Self-assembled CeVORSC advances · 2020Article
- Methods to Scale Down Graphene Oxide Size and Size Implication in Anti-cancer Applications.Frontiers in bioengineering and biotechnology · 2020Review
- Homogentisic acid-derived pigment as a biocompatible label for optoacoustic imaging of macrophages.Nature communications · 2019Article
- Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles.Advanced functional materials · 2018Article
- In vivo noninvasive analysis of graphene nanomaterial pharmacokinetics using photoacoustic flow cytometry.Journal of applied toxicology : JAT · 2017Article
- Plasmonic Nanoparticles with Quantitatively Controlled Bioconjugation for Photoacoustic Imaging of Live Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Article
- Monitoring/Imaging and Regenerative Agents for Enhancing Tissue Engineering Characterization and Therapies.Annals of biomedical engineering · 2016Review
- In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles.International journal of molecular sciences · 2015Review
- Quantitative photoacoustics to measure single cell melanin production and nanoparticle attachment.Physics in medicine and biology · 2015Article
- Optical drug monitoring: photoacoustic imaging of nanosensors to monitor therapeutic lithium in vivo.ACS nano · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Quantitative visualization of nanoparticles in cells and tissues, while preserving the spatial information, is very challenging. A photoacoustic imaging technique to depict the presence and quantity of nanoparticles is presented. This technique is based on the dependence of the photoacoustic signal on both the nanoparticle quantity and the laser fluence. Quantitative photoacoustic imaging is a robust technique that does not require knowledge of the local fluence, but a relative change in the fluence. This eliminates the need for sophisticated methods or models to determine the energy distribution of light in turbid media. Quantitative photoacoustic imaging was first applied to nanoparticle-loaded cells, and quantitation was validated by inductively coupled plasma mass spectrometry. Quantitative photoacoustic imaging was then extended to xenograft tumor tissue sections, and excellent agreement with traditional histopathological analysis was demonstrated. Our results suggest that quantitative photoacoustic imaging may be used in many applications including the determination of the efficiency and effectiveness of molecular targeting strategies for cell studies and animal models, the quantitative assessment of photoacoustic contrast agent biodistribution, and the validation of in vivo photoacoustic imaging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.