ArticleCell metabolism2013
Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma.
Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 94 citations in OpenAlex.
- A pilot randomized controlled trial of pioglitazone for the treatment of poorly controlled asthma in obesity.Respiratory research · 2015Trial
- Impact of a multidisciplinary intervention on resting and exercise respiratory functions in adolescents with obesity.Pediatric research · 2026Article
- The mechanistic role of adipokine imbalance in airway inflammation, hyperresponsiveness, and remodeling in obesity-related asthma.Frontiers in endocrinology · 2026Review
- Obesity-Associated Metabolomic and Functional Reprogramming in Neutrophils from Horses with Asthma.Animals : an open access journal from MDPI · 2025Article
- Relationship Between Plasma Leptin Levels and Airflow Limitation in the Small and Medium Airways in Young Adults.Journal of clinical medicine · 2025Article
- A clinician's guide to effects of obesity on childhood asthma and into adulthood.Expert review of respiratory medicine · 2024Review
- Association between waist circumference and lung function in American middle-aged and older adults: findings from NHANES 2007-2012.Journal of health, population, and nutrition · 2024Article
- COVID-19 and Pregnancy: A Dangerous Mix for Bone Turnover and Metabolism Biomarkers in Placenta and Colostrum.Journal of clinical medicine · 2024Article
- Obesity and Insulin Resistance in Asthma Pathogenesis and Clinical Outcomes.Biomedicines · 2024Review
- Obesity-associated Airway Hyperresponsiveness: Mechanisms Underlying Inflammatory Markers and Possible Pharmacological Interventions.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma.Paediatric drugs · 2023Review
- Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life.The World Allergy Organization journal · 2023Article
- Regulatory Peptides in Asthma.International journal of molecular sciences · 2021Review
- Association between sleep duration and asthma in different weight statuses (CHNS 2009-2015).Sleep & breathing = Schlaf & Atmung · 2021Article
- 2021 Brazilian Thoracic Association recommendations for the management of severe asthma.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2021Review
- Leptin in the Respiratory Tract: Is There a Role in SARS-CoV-2 Infection?Frontiers in physiology · 2021Review
- Leptin as a Predictor of Incident Asthma in Offspring of Obese Mothers.Annals of the American Thoracic Society · 2020Article
- Obesity Does Not Increase the Risk of Asthma Readmissions.Journal of clinical medicine · 2020Article
- Inhibiting the Notch signaling pathway suppresses Th17-associated airway hyperresponsiveness in obese asthmatic mice.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Mediation of the Acute Stress Response by the Skeleton.Cell metabolism · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Impaired lung function caused by decreased airway diameter (bronchoconstriction) is frequently observed whether body weight is abnormally high or low. That these opposite conditions affect the airways similarly suggests that the regulation of airway diameter and body weight are intertwined. We show here that, independently of its regulation of appetite, melanocortin pathway, or sympathetic tone, leptin is necessary and sufficient to increase airway diameter by signaling through its cognate receptor in cholinergic neurons. The latter decreases parasympathetic signaling through the M(3) muscarinic receptor in airway smooth muscle cells, thereby increasing airway diameter without affecting local inflammation. Accordingly, decreasing parasympathetic tone genetically or pharmacologically corrects bronchoconstriction and normalizes lung function in obese mice regardless of bronchial inflammation. This study reveals an adipocyte-dependent regulation of bronchial diameter whose disruption contributes to the impaired lung function caused by abnormal body weight. These findings may be of use in the management of obesity-associated asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.