ArticleBrain pathology (Zurich, Switzerland)2013
Attenuation of corpus callosum axon myelination and remyelination in the absence of circulating sex hormones.
Article in Brain pathology (Zurich, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Understanding the Role of Hypothalamic-Pituitary-Gonadal Axis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.Biomedicines · 2026Review
- Estradiol Promotes Myelin Repair in the Spinal Cord of Female Mice in a CXCR4 Chemokine Receptor-Independent Manner.International journal of molecular sciences · 2025Article
- Hormonal regulatory networks in spinal cord injury: mechanistic insights, crosstalk, and therapeutic innovations.Frontiers in endocrinology · 2025Review
- Sex-Specific Differences in Peripheral Nerve Properties: A Comparative Analysis of Conduction Velocity and Cross-Sectional Area in Upper and Lower Limbs.Diagnostics (Basel, Switzerland) · 2024Article
- The Effects of Neuroactive Steroids on Myelin in Health and Disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Review
- Effects of social rank and pubertal delay on brain structure in female rhesus macaques.Psychoneuroendocrinology · 2023Article
- Impact of endocrine dysregulation on disability and non-motor symptoms in pediatric onset multiple sclerosis.Frontiers in neurology · 2023Article
- Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration.Frontiers in molecular neuroscience · 2023Review
- Potential biological contributers to the sex difference in multiple sclerosis progression.Frontiers in immunology · 2023Article
- Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Pubertal Testosterone and the Structure of the Cerebral Cortex in Young Men.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function.Genes & development · 2021Review
- Cerebral White Matter Myelination and Relations to Age, Gender, and Cognition: A Selective Review.Frontiers in human neuroscience · 2021Review
- Reduced Inter-hemispheric Resting State Functional Connectivity and Its Association With Social Deficits in Autism.Frontiers in psychiatry · 2021Review
- CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis.Frontiers in cellular neuroscience · 2020Article
- Metabolic Activity in Central Neural Structures of Patients With Myocardial Injury.Journal of the American Heart Association · 2019Article
- Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury.CNS neuroscience & therapeutics · 2019Article
- Animal Weight Is an Important Variable for Reliable Cuprizone-Induced Demyelination.Journal of molecular neuroscience : MN · 2019Article
- Sex Differences in the Effect of Alcohol Drinking on Myelinated Axons in the Anterior Cingulate Cortex of Adolescent Rats.Brain sciences · 2019Article
- Functional Effects of Cuprizone-Induced Demyelination in the Presence of the mTOR-Inhibitor Rapamycin.Neuroscience · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Sex differences in the structure and organization of the corpus callosum (CC) can be attributed to genetic, hormonal or environmental effects, or a combination of these factors. To address the role of gonadal hormones on axon myelination, functional axon conduction and immunohistochemistry analysis of the CC in intact, gonadectomized and hormone-replaced gonadectomized animals were used. These groups were subjected to cuprizone diet-induced demyelination followed by remyelination. The myelinated component of callosal compound action potential was significantly decreased in ovariectomized and castrated animals under normal myelinating condition. Compared to gonadally intact cohorts, both gonadectomized groups displayed more severe demyelination and inhibited remyelination. Castration in males was more deleterious than ovariectomy in females. Callosal conduction in estradiol-supplemented ovariectomized females was significantly increased during normal myelination, less attenuated during demyelination, and increased beyond placebo-treated ovariectomized or intact female levels during remyelination. In castrated males, the non-aromatizing steroid dihydrotestosterone was less efficient than testosterone and estradiol in restoring normal myelination/axon conduction and remyelination to levels of intact males. Furthermore, in both sexes, estradiol supplementation in gonadectomized groups increased the number of oligodendrocytes. These studies suggest an essential role of estradiol to promote efficient CC myelination and axon conduction in both sexes.
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Registered trials
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