ArticleEuropean journal of immunology2013
Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.
Article in European journal of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Preselection CD4bioRxiv : the preprint server for biology · 2025Article
- Transcriptional network dynamics in early T cell development.The Journal of experimental medicine · 2024Review
- TOX as a potential target for immunotherapy in lymphocytic malignancies.Biomarker research · 2021Review
- SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8Nature communications · 2020Article
- Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells.Immunity · 2020Article
- [Expression and clinical significance of runt-related transcription factor 3 in children with bronchiolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Review
- Dysregulation of the TOX-RUNX3 pathway in cutaneous T-cell lymphoma.Oncotarget · 2019Article
- Article
- Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.Frontiers in immunology · 2018Article
- A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Combined Analysis of ChIP Sequencing and Gene Expression Dataset in Breast Cancer.Pathology oncology research : POR · 2017Article
- What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Estrogen-dependent downregulation of hypoxia-inducible factor (HIF)-2α in invasive breast cancer cells.Oncotarget · 2016Article
- Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Transcriptional and epigenetic networks of helper T and innate lymphoid cells.Immunological reviews · 2014Review
- GATA3: a master of many trades in immune regulation.Trends in immunology · 2014Review
- Transcriptional control of CD4 and CD8 coreceptor expression during T cell development.Cellular and molecular life sciences : CMLS · 2013Review
- Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
CD4(+) helper T cells are essential for immune responses and differentiate in the thymus from CD4(+) CD8(+) "double-positive" (DP) thymocytes. The transcription factor Runx3 inhibits CD4(+) T-cell differentiation by repressing Cd4 gene expression; accordingly, Runx3 is not expressed in DP thymocytes or developing CD4(+) T cells. The transcription factor Thpok is upregulated in CD4-differentiating thymocytes and required to repress Runx3. However, how Runx3 is controlled at early stages of CD4(+) T-cell differentiation, before the onset of Thpok expression, remains unknown. Here we show that Gata3, a transcription factor preferentially and transiently upregulated by CD4(+) T-cell precursors, represses Runx3 and binds the Runx3 locus in vivo. Accordingly, we show that high-level Gata3 expression and expression of Runx3 are mutually exclusive. Furthermore, whereas Runx3 represses Cd4, we show that Gata3 promotes Cd4 expression in Thpok-deficient thymocytes. Thus, in addition to its previously documented role in promoting CD4-lineage gene-expression, Gata3 represses CD8-lineage gene expression. These findings identify Gata3 as a critical pivot of CD4-CD8 lineage differentiation.
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