ArticlePloS one2013
Functional characterization of the short neuropeptide F receptor in the desert locust, Schistocerca gregaria.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 67 citations in OpenAlex.
- A signaling hub in the mosquito rectum coordinates reproductive investment after blood feeding.Current biology : CB · 2026Article
- Endocrine Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- A Signaling Hub in the Mosquito Rectum Coordinates Reproductive Investment After Blood Feeding.bioRxiv : the preprint server for biology · 2025Article
- A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.Nature communications · 2024Article
- Short neuropeptide F in integrated insect physiology.Journal of Zhejiang University. Science. B · 2024Review
- Article
- Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts.EMBO reports · 2022Article
- The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect.iScience · 2022Article
- Functional analysis of LFRFamide signaling in Pacific abalone, Haliotis discus hannai.PloS one · 2022Article
- Identification of the Short Neuropeptide F and Short Neuropeptide F Receptor Genes and Their Roles of Food Intake inInsects · 2021Article
- G-Protein Coupled Receptors (GPCRs) in Insects-A Potential Target for New Insecticide Development.Molecules (Basel, Switzerland) · 2021Review
- G-Protein Coupled Receptors (GPCRs): Signaling Pathways, Characterization, and Functions in Insect Physiology and Toxicology.International journal of molecular sciences · 2021Review
- Short neuropeptide F signaling regulates functioning of male reproductive system in Tenebrio molitor beetle.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling.eLife · 2020Article
- The Role of Peptide Hormones in Insect Lipid Metabolism.Frontiers in physiology · 2020Review
- Enteroendocrine peptides regulate feeding behavior via controlling intestinal contraction of the silkworm Bombyx mori.PloS one · 2019Article
- Regulation of Feeding and Metabolism by Neuropeptide F and Short Neuropeptide F in Invertebrates.Frontiers in endocrinology · 2019Review
- Interaction of neuropeptide F and diet levels effects carbonyl levels in grasshoppers.Experimental gerontology · 2018Article
- Inhibitory Role of the Mud Crab Short Neuropeptide F in Vitellogenesis and Oocyte Maturation via Autocrine/Paracrine Signaling.Frontiers in endocrinology · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas short neuropeptide F (sNPF) has already been reported to stimulate feeding behaviour in a variety of insect species, the opposite effect was observed in the desert locust. In the present study, we cloned a G protein-coupled receptor (GPCR) cDNA from the desert locust, Schistocerca gregaria. Cell-based functional analysis of this receptor indicated that it is activated by both known isoforms of Schgr-sNPF in a concentration dependent manner, with EC(50) values in the nanomolar range. This Schgr-sNPF receptor constitutes the first functionally characterized peptide GPCR in locusts. The in vivo effects of the sNPF signalling pathway on the regulation of feeding in locusts were further studied by knocking down the newly identified Schgr-sNPF receptor by means of RNA interference, as well as by means of peptide injection studies. While injection of sNPF caused an inhibitory effect on food uptake in the desert locust, knocking down the corresponding peptide receptor resulted in an increase of total food uptake when compared to control animals. This is the first comprehensive study in which a clearly negative correlation is described between the sNPF signalling pathway and feeding, prompting a reconsideration of the diverse roles of sNPFs in the physiology of insects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.