ArticlePloS one2013
A specialized microvascular domain in the mouse neural stem cell niche.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis.Acta physiologica (Oxford, England) · 2026Review
- Platelets regulate neural and oligodendroglial progenitors when infiltrating the brain parenchyma.Communications biology · 2025Article
- Sustaining Brain Youth by Neural Stem Cells: Physiological and Therapeutic Perspectives.Molecular neurobiology · 2025Review
- Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury.Cell communication and signaling : CCS · 2024Article
- Neonatal hyperoxia in mice triggers long-term cognitive deficits via impairments in cerebrovascular function and neurogenesis.The Journal of clinical investigation · 2022Article
- Review
- Telomeres and Telomerase in the Control of Stem Cells.Biomedicines · 2022Review
- Article
- Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain.International journal of molecular sciences · 2021Review
- Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats.Stem cell reports · 2021Article
- 3D Image Analysis of the Complete Ventricular-Subventricular Zone Stem Cell Niche Reveals Significant Vasculature Changes and Progenitor Deficits in Males Versus Females with Aging.Stem cell reports · 2021Article
- Do not keep it simple: recent advances in the generation of complex organoids.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Neural stem cell niche heterogeneity.Seminars in cell & developmental biology · 2019Review
- Blood Vessels as Regulators of Neural Stem Cell Properties.Frontiers in molecular neuroscience · 2019Review
- Article
- Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis.Communications biology · 2018Article
- Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.Nature cell biology · 2017Article
- How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System.Frontiers in cellular neuroscience · 2016Article
- Article
- Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance.World journal of stem cells · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The microenvironment of the subependymal zone (SEZ) neural stem cell niche is necessary for regulating adult neurogenesis. In particular, signaling from the microvasculature is essential for adult neural stem cell maintenance, but microvascular structure and blood flow dynamics in the SEZ are not well understood. In this work, we show that the mouse SEZ constitutes a specialized microvascular domain defined by unique vessel architecture and reduced rates of blood flow. Additionally, we demonstrate that hypoxic conditions are detectable in the ependymal layer that lines the ventricle, and in a subpopulation of neurons throughout the SEZ and striatum. Together, these data highlight previously unidentified features of the SEZ neural stem cell niche, and further demonstrate the extent of microvascular specialization in the SEZ microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.