ArticlePloS one2013
Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- The oncogene Musashi1 encodes novel miRNAs in breast cancer.Scientific reports · 2023Article
- Article
- Characterization of Two Novel EF-Hand Proteins Identifies a Clade of Putative CaJournal of bioinformatics and systems biology : Open access · 2022Article
- Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis.Molecular biology of the cell · 2021Article
- Musashi1 expression is negatively correlated with numb expression in brain metastases.Medicine · 2020Article
- Identification and Validation of anCancers · 2020Article
- Upregulation of musashi1 increases malignancy of hepatocellular carcinoma via the Wnt/β-catenin signaling pathway and predicts a poor prognosis.BMC gastroenterology · 2019Article
- Increased Expression of Musashi-1 Evidences Mesenchymal Repair in Maxillary Sinus Floor Elevation.Scientific reports · 2018Article
- Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.BMC cancer · 2018Article
- Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation.International journal of cancer research & therapy · 2018Article
- Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Review
- Suppression of intestinal tumorigenesis inJournal of cell science · 2017Article
- RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA.The Journal of biological chemistry · 2016Article
- The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.Molecular and cellular biology · 2016Article
- Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.Molecular oncology · 2015Article
- Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis.BioMed research international · 2015Article
- A conserved three-nucleotide core motif defines Musashi RNA binding specificity.The Journal of biological chemistry · 2014Article
- Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.eLife · 2014Article
- Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2.The Journal of biological chemistry · 2014Article
- Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa.Gene expression patterns : GEP · 2014Article
Corrections and comments
- Expression of concern · 2013-01-04Conflict of Interest ·
- Expression of concern
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveUpregulation of the RNA-binding protein Musashi-1 (Msi1) has been shown to occur in rat gastric corpus mucosa after ethanol-induced mucosal injury. However, there is no direct evidence linking Msi1 with gastric regeneration. We examined the process of tissue repair after acute gastric mucosal injury with Msi1-knock-out (KO) mice to clarify the role of Msi1 and Msi1-dependent regulation of m-Numb expression in regenerating gastric mucosa.
methodsAcute gastric injury was induced in Msi1-KO and wild-type ICR mice by administering absolute ethanol. Expression of the splicing variants of m-Numb mRNA and protein in the gastric mucosa were analyzed by quantitative RT-PCR and western blotting, respectively.
resultsWe demonstrated that phosphotyrosine-binding domain-containing m-Numb expression was significantly upregulated at both the mRNA and protein levels in wild-type mice at 3 h after ethanol-induced acute gastric injury. In contrast, in Msi1-KO mice, the m-Numb protein was expressed weakly, and was associated with delayed regeneration of the injured gastric mucosal epithelium. In the Msi1-KO mouse, the ratio of m-Numb mRNA to total m-Numb mRNA in the heavy polysome fractions was lower than that in the wild-type mouse. Further, we showed that m-Numb-enhancement in gastric mucous cells induced the expression of prostate stem cell antigen and metallothionein-2. Under the m-Numb enhancing condition, the gastric cells exhibited enhanced cell proliferation and were significantly more resistant to H(2)O(2)-induced cell death than control cells.
conclusionsMsi1-dependent post-transcriptional enhancement of m-Numb is crucial in gastric epithelial regeneration.
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