ArticlePloS one2013
Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- High-resolution adaptive optics retinal imaging of cellular structure in choroideremia.Investigative ophthalmology & visual science · 2014Trial
- Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid.Investigative ophthalmology & visual science · 2026Article
- Establishment of an in vitro choroid complex system for vascular response screening.Scientific reports · 2024Article
- Variability in Retinal Neuron Populations and Associated Variations in Mass Transport Systems of the Retina in Health and Aging.Frontiers in aging neuroscience · 2022Review
- Article
- Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid.International journal of molecular sciences · 2020Article
- Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2016Article
- Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.The Journal of clinical investigation · 2016Article
- Targeting pericytes for angiogenic therapies.Microcirculation (New York, N.Y. : 1994) · 2014Review
- Vascular associations and dynamic process motility in perivascular myeloid cells of the mouse choroid: implications for function and senescent change.Investigative ophthalmology & visual science · 2014Article
- Paradoxical effects of heme arginate on survival of myocutaneous flaps.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin.International journal of ophthalmology · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePerivascular mural cells of the choroid have been implicated in physiological functioning as well as in retinal disease pathogenesis. However details regarding their form and function are not well understood. We aim to characterize choroidal mural cells in the adult mouse choroid in terms of their distribution and morphology, and correlate these to their contractile behavior.
methodsSclerochoroidal flat-mounted explants were prepared from albino transgenic mice in which the α-smooth muscle actin (α-SMA) promoter drives the expression of green fluorescent protein (GFP). α-SMA-expressing smooth muscle cells and pericytes in the living choroid were thereby rendered fluorescent and imaged with confocal microscopy and live-cell imaging in situ.
resultsChoroidal perivascular mural cells demonstrate significant diversity in terms of their distribution and morphology at different levels of the vasculature. They range from densely-packed circumferentially-oriented cells that provide complete vascular coverage in primary arteries to widely-spaced stellate-shaped cells that are distributed sparsely over terminal arterioles. Mural cells at each level are immunopositive for contractile proteins α-SMA and desmin and demonstrate vasoconstrictory contractile movements in response to endothelin-1 and the calcium ionophore, A23187, and vasodilation in response to the calcium chelator, BAPTA. The prominence of vasoregulatory contractile responses varies with mural cell morphology and density, and is greater in vessels with dense coverage of mural cells with circumferential cellular morphologies. In the choriocapillaris, pericytes demonstrate a sparse, horizontal distribution and are selectively distributed only to the scleral surface of the choriocapillaris.
conclusionsDiversity and regional specialization of perivascular mural cells may subserve varying requirements for vasoregulation in the choroid. The model of the α-SMA-GFP transgenic albino mouse provides a useful and intact system for the morphological and functional study of choroidal mural cells.
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