ArticlePloS one2013
Developmental and visual input-dependent regulation of the CB1 cannabinoid receptor in the mouse visual cortex.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Motion and form perception in healthy individuals with adolescent cannabis use.Frontiers in psychiatry · 2026Article
- Inhibitory maturation and ocular dominance plasticity in mouse visual cortex require astrocyte CB1 receptors.iScience · 2024Article
- Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids.iScience · 2024Article
- MAM-2201 acute administration impairs motor, sensorimotor, prepulse inhibition, and memory functions in mice: a comparison with its analogue AM-2201.Psychopharmacology · 2023Article
- Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CBMicrobial cell factories · 2022Article
- Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons.Cell reports · 2022Article
- In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice.International journal of molecular sciences · 2022Article
- Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex.Molecules (Basel, Switzerland) · 2021Article
- Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1.Histochemistry and cell biology · 2021Article
- Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats.Frontiers in neuroscience · 2019Article
- Cannabinoids Modulate Light Signaling in ON-Sustained Retinal Ganglion Cells of the Mouse.Frontiers in neural circuits · 2019Article
- Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Timing-dependent LTP and LTD in mouse primary visual cortex following different visual deprivation models.PloS one · 2017Article
- Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.Psychopharmacology · 2016Article
- Developmental Switch in Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization of the Thalamocortical Projection in the Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Expression and Function of the Endocannabinoid System in the Retina and the Visual Brain.Neural plasticity · 2016Review
- Cannabinoid-dependent potentiation of inhibition at eye opening in mouse V1.Frontiers in cellular neuroscience · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian visual system exhibits significant experience-induced plasticity in the early postnatal period. While physiological studies have revealed the contribution of the CB1 cannabinoid receptor (CB1) to developmental plasticity in the primary visual cortex (V1), it remains unknown whether the expression and localization of CB1 is regulated during development or by visual experience. To explore a possible role of the endocannabinoid system in visual cortical plasticity, we examined the expression of CB1 in the visual cortex of mice. We found intense CB1 immunoreactivity in layers II/III and VI. CB1 mainly localized at vesicular GABA transporter-positive inhibitory nerve terminals. The amount of CB1 protein increased throughout development, and the specific laminar pattern of CB1 appeared at P20 and remained until adulthood. Dark rearing from birth to P30 decreased the amount of CB1 protein in V1 and altered the synaptic localization of CB1 in the deep layer. Dark rearing until P50, however, did not influence the expression of CB1. Brief monocular deprivation for 2 days upregulated the localization of CB1 at inhibitory nerve terminals in the deep layer. Taken together, the expression and the localization of CB1 are developmentally regulated, and both parameters are influenced by visual experience.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.