ArticlePloS one2013
Effect of aripiprazole on mismatch negativity (MMN) in schizophrenia.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia.Schizophrenia research · 2018Pooled it
- Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.Clinical EEG and neuroscience · 2017Pooled it
- Trial
- Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia.PloS one · 2013Trial
- Altered theta band and theta/beta ratio in mismatch negativity associate with treatment effect in schizophrenia with auditory hallucinations.Schizophrenia research. Cognition · 2025Article
- Novel approaches to EEG and MEG in motor neurone disease: IFCN Handbook Chapter.Clinical neurophysiology practice · 2025Review
- Effect of antipsychotic on mismatch negativity amplitude and evoked theta power in drug-naïve patients with schizophrenia.BMC psychiatry · 2024Article
- Transient changes in mismatch negativity after two sessions of electroconvulsive therapy for atypical psychosis: A case report.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Target engagement of the subgenual anterior cingulate cortex with transcranial temporal interference stimulation in major depressive disorder: a protocol for a randomized sham-controlled trial.Frontiers in neuroscience · 2024Article
- Mismatch negativity and clinical trajectories in psychotic disorders: Five-year stability and predictive utility.Psychological medicine · 2023Article
- Neurophysiology in psychosis: The quest for disease biomarkers.Translational psychiatry · 2022Review
- The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats.Neuropsychopharmacology reports · 2021Article
- Use of cognitive event-related potentials in the management of psychiatric disorders: Towards an individual follow-up and multi-component clinical approach.World journal of psychiatry · 2021Review
- Evaluation of multi-feature auditory deviance detection in Parkinson's disease: a mismatch negativity study.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Individuals With Autism Have No Detectable Deficit in Neural Markers of Prediction Error When Presented With Auditory Rhythms of Varied Temporal Complexity.Autism research : official journal of the International Society for Autism Research · 2020Article
- Stimulus-Specific Adaptation Decreases the Coupling of Spikes to LFP Phase.Frontiers in neural circuits · 2019Article
- Electrophysiological Evidence in Schizophrenia in Relation to Treatment Response.Frontiers in psychiatry · 2018Review
- Mismatch Negativity in Han Chinese Patients with Schizophrenia: A Meta-Analysis.Shanghai archives of psychiatry · 2017Review
- Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review.Therapeutics and clinical risk management · 2017Review
- Effects of Blocking D2/D3 Receptors on Mismatch Negativity and P3a Amplitude of Initially Antipsychotic Naïve, First Episode Schizophrenia Patients.The international journal of neuropsychopharmacology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive deficits are considered core symptoms of the schizophrenia. Cognitive function has been found to be a better predictor of functional outcome than symptom levels. Changed mismatch negativity (MMN) reflects abnormalities of early auditory processing in schizophrenia. Up to now, no studies for the effects of aripiprazole on MMN in schizophrenia have been reported. METHODOLOGY/PRINCIPAL
findingsSubjects included 26 patients with schizophrenia, and 26 controls. Psychopathology was rated in patients with the Positive and Negative Syndrome Scale (PANSS) at baseline, after 4- and 8-week treatments with aripiprazole. Auditory stimuli for ERP consisted of 100 millisecond/1000 Hz standards, intermixed with 100 millisecond/1500 Hz frequency deviants and 250 millisecond/1000 Hz duration deviants. EEG was recorded at Fz. BESA 5.1.8 was used to perform data analysis. MMN waveforms were obtained by subtracting waveforms elicited by standards from waveforms elicited by frequency- or duration-deviant stimuli. Aripiprazole decreased all PANSS. Patients showed smaller mean amplitudes of frequency and duration MMN at baseline than did controls. A repeated measure ANOVA with sessions (i.e., baseline, 4- and 8-week treatments) and MMN type (frequency vs. duration) as within-subject factors revealed no significant MMN type or MMN type × session main effect for MMN amplitudes. Session main effect was significant. LSD tests demonstrated significant differences between MMN amplitudes at 8 weeks and those at both baseline and 4 weeks. There was significant negative correlation between changes in amplitudes of frequency and duration MMN and changes in PANSS total scores at baseline and follow-up periods.
conclusionsAripiprazole improved the amplitudes of MMN. MMN offers objective evidence that treatment with the aripiprazole may ameliorate preattentive deficits in schizophrenia.
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