ArticleInvestigative ophthalmology & visual science2013
Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- MKK4 and MKK7 control degeneration of retinal ganglion cell somas and axons after glaucoma-relevant injury.Cell death discovery · 2025Article
- Context-Dependent Effects of the Ketogenic Diet on Retinal Ganglion Cell Survival and Axonal Regeneration After Optic Nerve Injury.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023Article
- Assessment of the uniform field electroretinogram for mouse retinal ganglion cell functional analysis.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Morpho-Functional Assessment of Retinal Ganglion Cells and Visual Pathways in Patients with Optic Disc Drusen: Superficial Drusen Visible Height as a Marker of Impairment.Journal of clinical medicine · 2023Article
- Natural History of Glaucoma Progression in the DBA/2J Model: Early Contribution of Müller Cell Gliosis.Cells · 2023Article
- Longitudinal in vivo CaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Associations between steady-state pattern electroretinography and estimated retinal ganglion cell count in glaucoma suspects.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Article
- Using Noninvasive Electrophysiology to Determine Time Windows of Neuroprotection in Optic Neuropathies.International journal of molecular sciences · 2022Article
- Retrograde Optic Nerve Degeneration in Pituitary Adenoma: A Study with RE-PERG.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Oral administration of a dual ETMolecular vision · 2022Article
- Review
- Longitudinal Morphological and Functional Assessment of RGC Neurodegeneration After Optic Nerve Crush in Mouse.Frontiers in cellular neuroscience · 2020Article
- Target-Derived Neurotrophic Factor Deprivation Puts Retinal Ganglion Cells on Death Row: Cold Hard Evidence and Caveats.International journal of molecular sciences · 2019Review
- The Role of Deimination in Regenerative Reprogramming of Neurons.Molecular neurobiology · 2019Article
- Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma.International journal of molecular sciences · 2018Article
- Low-Intensity Pulsed Ultrasound Protects Retinal Ganglion Cell From Optic Nerve Injury Induced Apoptosis via Yes Associated Protein.Frontiers in cellular neuroscience · 2018Article
- Evaluating retinal ganglion cell loss and dysfunction.Experimental eye research · 2016Review
- Integrative properties of retinal ganglion cell electrical responsiveness depend on neurotrophic support and genotype in the mouse.Experimental eye research · 2016Article
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4 authors.
Funding
Abstract
purposeWe investigated the role of retrograde signaling in the optic nerve on retinal ganglion cell (RGC) electrical responsiveness in the mouse model.
methodsElectrical response of RGC was measured by pattern electroretinogram (PERG) in 43 C57BL/6J mice 4 to 6 months old under ketamine/xylazine anesthesia. PERGs were recorded before and at different times after blockade of axon transport with lidocaine at either the retrobulbar level (2 μL, 40 μg/μL) or at level of the superior colliculus (SC, 1 μL, 40 μg/μL). PERGs also were recorded before and at different times after optic nerve crush 1.5 mm behind the eye, followed by TUJ1-positive RGC counts of excised retinas. As controls, PERGs also were recorded after either saline injections or sham optic nerve surgery. The photopic flash electroretinogram (FERG) and visual evoked potential (FVEP) also were recorded before lidocaine and at relevant times afterwards.
resultsLidocaine injection caused rapid (retrobulbar ~10 minutes, SC 1 hour), reversible reduction of PERG amplitude (≥50%). Optic nerve crush caused rapid (10-20 minutes), irreversible reduction of PERG amplitude (70-75%), increase of PERG latency (>25%), as well as RGC loss (88%) 1 month after crush. FVEP was unaltered by lidocaine. For all procedures, the FERG was unaltered.
conclusionsAs experimental interventions were made at postretinal level(s), PERG changes were likely associated with altered supply of retrogradely-delivered material from the SC. This implies that retrograde transport of target-derived molecules is necessary for normal RGC electrical responsiveness. The time course of early PERG changes is consistent with the speed of fast retrograde axon transport.
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