ArticleCerebral cortex (New York, N.Y. : 1991)2014
Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
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- Intrinsic coordination of dynamic molecular signatures shape the human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology.bioRxiv : the preprint server for biology · 2025Article
- Unravelling the conundrum of nucleolar NR2F1 localization using antibody-based approaches in vitro and in vivo.Communications biology · 2025Article
- The Principle of Cortical Development and Evolution.Neuroscience bulletin · 2025Review
- Article
- Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Evaluation of advances in cortical development using model systems.Developmental neurobiology · 2022Review
- A role for sustained MAPK activity in the mouse ventral telencephalon.Developmental biology · 2021Article
- Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Structural and Functional Aspects of the Neurodevelopmental GeneFrontiers in molecular neuroscience · 2021Review
- The Stemness Gene Mex3A Is a Key Regulator of Neuroblast Proliferation During Neurogenesis.Frontiers in cell and developmental biology · 2020Article
- Limit cycle dynamics can guide the evolution of gene regulatory networks towards point attractors.Scientific reports · 2019Article
- New insights into the development of the human cerebral cortex.Journal of anatomy · 2019Review
- Beyond protein-coding genes.eLife · 2019Article
- The novel lncRNAeLife · 2019Article
- Developmental interactions between thalamus and cortex: a true love reciprocal story.Current opinion in neurobiology · 2018Review
- A dual role for the transcription factor Sp8 in postnatal neurogenesis.Scientific reports · 2018Article
- The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.Stem cell reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
To gain new insights into the transcriptional regulation of cortical development, we examined the role of the transcription factor Sp8, which is downstream of Fgf8 signaling and known to promote rostral cortical development. We have used a binary transgenic system to express Sp8 throughout the mouse telencephalon in a temporally restricted manner. Our results show that misexpression of Sp8 throughout the telencephalon, at early but not late embryonic stages, results in cortical hypoplasia, which is accompanied by increased cell death, reduced proliferation, and precocious neuronal differentiation. Misexpression of Sp8 at early developmental stages represses COUP-TF1 expression, a negative effector of Fgf signaling and a key promoter of posterior cortical identity, while ablation of Sp8 has the opposite effect. In addition, transgenic misexpression of COUP-TF1 resulted in downregulation of Sp8, indicating a reciprocal cross-regulation between these 2 transcription factors. Although Sp8 has been suggested to induce and/or maintain Fgf8 expression in the embryonic telencephalon, neither Fgf8 nor Fgf15 was upregulated using our gain-of-function approach. However, misexpression of Sp8 greatly increased the expression of Fgf target molecules, suggesting enhanced Fgf signaling. Thus, we propose that Sp8 promotes rostral and dorsomedial cortical development by repressing COUP-TF1 and promoting Fgf signaling in pallial progenitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.