ArticleCerebral cortex (New York, N.Y. : 1991)2014
Pharmacological dissociation of novelty responses in the human brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Trial
- Reduced Reward Processing in Schizophrenia: A Comprehensive EEG Event-Related Oscillation Study.Brain topography · 2024Article
- Levodopa suppresses grid-like activity and impairs spatial learning in novel environments in healthy young adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Effects of exploring a novel environment on memory across the lifespan.Scientific reports · 2022Article
- Age-associated gut microbiota impair hippocampus-dependent memory in a vagus-dependent manner.JCI insight · 2022Article
- Article
- Evidence and implications of abnormal predictive coding in dementia.Brain : a journal of neurology · 2021Review
- Anticipation of novel environments enhances memory for incidental information.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Stable habituation deficits in the early stage of psychosis: a 2-year follow-up study.Translational psychiatry · 2021Article
- Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults-A randomized controlled double-blinded crossover study.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- The gains of a 4-week cognitive training are not modulated by novelty.Human brain mapping · 2020Article
- Novelty Improves the Formation and Persistence of Memory in a Naturalistic School Scenario.Frontiers in psychology · 2020Article
- Dopamine Related Genes Differentially Affect Declarative Long-Term Memory in Healthy Humans.Frontiers in behavioral neuroscience · 2020Article
- Neuroimaging of reward mechanisms in Gambling disorder: an integrative review.Molecular psychiatry · 2019Review
- Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.Frontiers in psychology · 2019Article
- Novelty Before or After Word Learning Does Not Affect Subsequent Memory Performance.Frontiers in psychology · 2019Article
- Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study.Translational psychiatry · 2018Article
- Knowledge acquisition is governed by striatal prediction errors.Nature communications · 2018Article
- Retrieval Demands Adaptively Change Striatal Old/New Signals and Boost Subsequent Long-Term Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A circuit-based mechanism underlying familiarity signaling and the preference for novelty.Nature neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Repeated processing of the same information is associated with decreased neuronal responses, termed repetition suppression (RS). Although RS effects (i.e., the difference in activity between novel and repeated stimuli) have been demonstrated within several brain regions, such as the medial temporal lobe, their precise neural mechanisms still remain unclear. Here, we used functional magnetic resonance imaging together with psychopharmacology in 48 healthy human subjects, demonstrating that RS effects within the mesolimbic system are differentially modulated by cholinergic and dopaminergic stimulation. The dopamine precursor levodopa (100 mg) attenuated RS within the hippocampus, parahippocampal cortex, and substantia nigra/ventral tegmental area, and the degree of this reduction correlated with recognition memory performance 24 h later. The acetylcholinesterase inhibitor galantamine (8 mg), in contrast, reversed RS into repetition enhancement, showing no relationship to subsequent recognition memory. This suggests that novelty sensitive neural populations of the mesolimbic system can dynamically shift their responses depending on the balance of cholinergic and dopaminergic neurotransmission, and these shifts can influence memory retention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.