ReviewCurrent rheumatology reports2013
Genetics of hyperuricemia and gout: implications for the present and future.
Review in Current rheumatology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Analysis of risk factors for kidney stones in patients with hyperuricemia: a cross-sectional study based on NHANES.Translational andrology and urology · 2025Article
- The Therapeutic Management of Chemical and Herbal Medications on Uric Acid Levels and Gout: Modern and Traditional Wisdom.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Mechanism of flavonoids in the treatment of gouty arthritis (Review).Molecular medicine reports · 2024Review
- Triglycerides and HDL Cholesterol Mediate the Association Between Waist Circumference and Hyperuricemia in Normal-Weight Men.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association and interaction between dietary patterns and gene polymorphisms in Liangshan residents with hyperuricemia.Scientific reports · 2022Article
- Article
- Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion.Frontiers in pharmacology · 2020Article
- Update on the epidemiology, genetics, and therapeutic options of hyperuricemia.American journal of translational research · 2020Review
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.Nature genetics · 2019Article
- Dietary factors are associated with serum uric acid trajectory differentially by race among urban adults.The British journal of nutrition · 2018Article
- Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery.Frontiers in chemistry · 2018Review
- Genetic risk scores, sex and dietary factors interact to alter serum uric acid trajectory among African-American urban adults.The British journal of nutrition · 2017Article
- Lumbar spinal stenosis attributable to tophaceous gout: case report and review of the literature.Therapeutics and clinical risk management · 2017Article
- Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong.Personalized medicine · 2016Article
- WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients.Rheumatology international · 2016Article
- Associations between interleukin and interleukin receptor gene polymorphisms and risk of gout.Scientific reports · 2015Article
- Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways.Biochemistry and biophysics reports · 2015Article
- SLC transporters as therapeutic targets: emerging opportunities.Nature reviews. Drug discovery · 2015Review
- Uric acid and cardiac performance.Internal and emergency medicine · 2014Article
- Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population.International journal of molecular sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gout is the most common inflammatory arthropathy and occurs in the setting of elevated serum urate levels. Gout is also known to be associated with multiple comorbidities including cardiovascular disease and the metabolic syndrome. Recent advances in research have increased our understanding and improved our knowledge of the pathophysiology of gout. Genome-wide association studies have permitted the identification of several new and common genetic factors that contribute to hyperuricemia and gout. Most of these are involved with the renal urate transport system (the uric acid transportasome), generally considered the most influential regulator of serum urate homeostasis. Thus far, SCL22A12, SCL2A9, and GLUT9 have been found to have the greatest variation and most influence on serum urate levels. However, genetics are only a part of the explanation in the development of hyperuricemia and gout. As results have been mixed, the role of known urate influential genes in gout's associated comorbidities remains unclear. Regardless, GWAS findings have expanded our understanding of the pathophysiology of hyperuricemia and gout, and will likely play a role in the development of future therapies and treatment of this ancient disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.