ArticleMolecular neurobiology2013
Anxiolytic actions of motilin in the basolateral amygdala.
Article in Molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors.Frontiers in neuroscience · 2023Article
- Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents.Pharmacology research & perspectives · 2022Review
- Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin.Life (Basel, Switzerland) · 2021Review
- Tea polyphenols protect learning and memory in sleep-deprived mice by promoting AMPA receptor internalization.Neuroreport · 2020Article
- Efficacy and safety of acupuncture combined with western medicine for anxiety: A systematic review protocol.Medicine · 2020Article
- CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice.The Journal of clinical investigation · 2019Article
- Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases.Frontiers in neuroscience · 2018Review
- Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice.Scientific reports · 2017Article
- Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.Neuromolecular medicine · 2014Article
- Effect of baclofen on morphine-induced conditioned place preference, extinction, and stress-induced reinstatement in chronically stressed mice.Psychopharmacology · 2014Article
- Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model.Molecular painArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anxiety. However, little is known about the role of motilin in BLA neuronal circuits and the molecular mechanisms of stress-related anxiety. Whole-cell recordings from amygdala slices showed that motilin depolarized the interneurons and facilitated GABAergic transmission in the BLA, which is mimicked by the motilin receptor agonist, erythromycin. BLA local injection of erythromycin or motilin can reduce the anxiety-like behavior in mice after acute stress. Therefore, motilin is essential in regulating interneuron excitability and GABAergic transmission in BLA. Moreover, the anxiolytic actions of motilin can partly be explained by modulating the BLA neuronal circuits. The present data demonstrate the importance of motilin in anxiety and the development of motilin receptor non-peptide agonist as a clear target for the potential treatment of anxiety disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.