SynthesisMolecular biology reports2013
Glutathione S-transferase polymorphisms, asthma susceptibility and confounding variables: a meta-analysis.
Synthesis in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Association of glutathione S-transferase M1 and T1 genotypes with asthma: A meta-analysis.Medicine · 2020Pooled it
- Dietary patterns, lung function and asthma in childhood: a longitudinal study.Respiratory research · 2023Article
- Association between Glutathione S-Transferases Gene Variants and COVID-19 Severity in Previously Vaccinated and Unvaccinated Polish Patients with Confirmed SARS-CoV-2 Infection.International journal of environmental research and public health · 2023Article
- Editorial: The expanding functional network of glutathione transferases.Frontiers in molecular biosciences · 2023Article
- The role of gene-ambient air pollution interactions in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Interactions between glutathione S-transferase genes and household air pollution on asthma and lung function.Frontiers in molecular biosciences · 2022Review
- Glutathione S-Transferase Gene Associations and Gene-Environment Interactions for Asthma.Current allergy and asthma reports · 2021Review
- Endoplasmic reticulum stress and glutathione therapeutics in chronic lung diseases.Redox biology · 2020Review
- Dysregulation of the glutaredoxin/American journal of physiology. Cell physiology · 2020Article
- The morbidity and mortality of COVID-19 are correlated with the Ile105Val glutathioneThe Egyptian journal of medical human genetics · 2020Article
- Associations Between Glutathione-S-Transferase Genotypes and Bronchial Hyperreactivity Patients With Di-isocyanate Induced Asthma. A Follow-Up Study.Frontiers in medicine · 2019Article
- Variants in genes coding for glutathione S-transferases and asthma outcomes in children.Pharmacogenomics · 2018Article
- Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma.Allergy, asthma & immunology research · 2018Article
- Interactions of GST Polymorphisms in Air Pollution Exposure and Respiratory Diseases and Allergies.Current allergy and asthma reports · 2016Review
- Children's Inter-Individual Variability and Asthma Development.International journal of health sciences · 2015Review
- Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study.Pediatric research · 2015Article
- A pooled multisite analysis of the effects of atopic medical conditions in glioma risk in different ethnic groups.Annals of epidemiology · 2015Article
- Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: A Systematic Review and Meta-analysis.Allergy, asthma & immunology research · 2015Article
- GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study.Environmental health perspectives · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is one of the main risk factors for asthma development. Glutathione S-transferases play an important role in antioxidant defences and may influence asthma susceptibility. In particular, GSTM1 and GSTT1 positive/null genotypes and the GSTP1 Ile105 Val polymorphism have been analyzed in a number of genetic association studies, with conflicting outcomes. Two previous meta-analyses have attempted to clarify the associations between GST genes and asthma, but these studies have also showed contrasting results. Our aim was to perform a meta-analysis that included independent genetic association studies on GSTM1, GSTP1, and GSTT1, evaluating also the effect of potential confounding variables (i.e. ethnicity, population age, and urbanization). Systematic review and meta-analysis of the effects of GST genes on asthma were conducted. The meta-analyses were performed using a fixed or, where appropriate, random effects model. The meta-analysis of the GSTM1 (n = 35), GSTT1 (n = 31) and GSTP1 (n = 28) studies suggests that no significant associations with asthma susceptibility were observed for GSTM1 and GSTP1 gene polymorphisms, whereas a significant outcome was detected for the GSTT1 positive/null genotype (pooled OR = 1.33, 95 %CI = 1.10-1.60). However, high between-study heterogeneity was identified in all the general analyses (p heterogenetity < 0.05). The stratification analysis seems to explain the heterogeneity only in few cases. This picture is probably due to the interactive process of genetics and environment that characterizes disease pathogenesis. Further studies on interactions of GST genes with the potential oxidative stress sources and with other antioxidant genes are needed to explain the role of GST enzymes in asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.