Trial reportJAMA ophthalmology2013
Fluoroquinolone treatment and susceptibility of isolates from bacterial keratitis.
Trial report in JAMA ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00324168 (Steroids for Corneal Ulcers Trial), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Steroids for Corneal Ulcers Trial
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Topical corticosteroids as adjunctive therapy for bacterial keratitis.The Cochrane database of systematic reviews · 2014Pooled it
- The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial.American journal of ophthalmology · 2017Trial
- Effect of pretreatment with antifungal agents on clinical outcomes in fungal keratitis.Clinical & experimental ophthalmology · 2016Trial
- Association of pretreatment with antifungal medication and fungal resistance in the mycotic ulcer treatment trial I.JAMA ophthalmology · 2015Trial
- Multidrug antifungal resistance and clinical outcomes in fungal keratitis: a prospective study in a South Indian population.Eye (London, England) · 2026Article
- Effects of repeated culture in sub-inhibitory concentrations of ciprofloxacin on resistance and genetic characteristics of an ocular Pseudomonas aeruginosa isolate.World journal of microbiology & biotechnology · 2026Article
- First report of Stemphylium lycopersici keratitis, a complex corneal infection case.Journal of ophthalmic inflammation and infection · 2025Article
- Contact Lens-AssociatedClinical optometry · 2025Article
- Predisposing factors, clinical and microbiological insights of bacterial keratitis: analysis of 354 cases from a leading French academic centre.The British journal of ophthalmology · 2024Article
- Article
- Effectiveness of laser pulsed irradiation for antimicrobial photodynamic therapy.Lasers in medical science · 2024Article
- Mild Pulmonary Nocardiosis Caused by Nocardia terpenica in an Immunocompetent Patient.Internal medicine (Tokyo, Japan) · 2023Article
- Antimicrobial resistance in topical treatments for microbial keratitis: protocol for a systematic review and meta-analysis.BMJ open · 2023Article
- Nocardia infection following ocular surface surgery.International ophthalmology · 2023Article
- Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study.Indian journal of ophthalmology · 2022Article
- Foundational concepts in the biology of bacterial keratitis.Experimental eye research · 2021Review
- Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.Eye (London, England) · 2021Review
- Evaluation of Toluidine Blue-Mediated Photodynamic Therapy for Experimental Bacterial Keratitis in Rabbits.Translational vision science & technology · 2020Article
- In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy onTranslational vision science & technology · 2019Article
- Microbiological Profile of Corneal Ulcers at a Tertiary Referral Center.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo analyze the relationship between fluoroquinolone use at presentation and minimum inhibitory concentration in bacterial keratitis.
methodsThe Steroids for Corneal Ulcers Trial was a randomized, double-masked, placebo-controlled trial assessing the effect of adjunctive topical corticosteroid treatment on outcomes in bacterial keratitis. After presentation, all patients were treated with moxifloxacin hydrochloride, 0.5%. We compare antibiotic use at presentation with minimum inhibitory concentration against moxifloxacin for all isolates. Separate analyses accounted for organism species and fluoroquinolone generation.
resultsTopical fluoroquinolone use at presentation was reported in 92 of 480 cases (19.2%). Causative organisms in the 480 cases included Streptococcus pneumoniae (247 cases [51.5%]), Pseudomonas aeruginosa (109 cases [22.7%]), and Nocardia species (55 cases [11.5%]). Isolates from patients who reported fluoroquinolone use at presentation had a 2.01-fold-higher minimum inhibitory concentration (95% CI, 1.39-fold to 2.91-fold; P < .001). Fourth-generation fluoroquinolones were associated with a 3.48-fold-higher minimum inhibitory concentration than those isolates that were not exposed to pretreatment at enrollment (95% CI, 1.99-fold to 6.06-fold; P < .001).
conclusionThis study provides evidence that prior use of fluoroquinolones is associated with antibiotic resistance.
trial registrationclinicaltrials.gov Identifier: NCT00324168.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.