SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Effects of exercise on fracture reduction in older adults: a systematic review and meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Exercise for fracture prevention - evidence and consensus-based practice guideline of the osteology umbrella association (DVO).BMC endocrine disorders · 2026Guideline
- [Physical training for fracture prevention : Evidence- and consensus-based practice recommendations of the updated DVO guideline].Orthopadie (Heidelberg, Germany) · 2025Guideline
- Impact of exercise modalities on bone health: a meta-analysis of aerobic, resistance, and combined training on bone mineral density in postmenopausal women.Archives of osteoporosis · 2025Pooled it
- The effect of physical activity intervention and detraining on postmenopausal osteopenia and osteoporosis: a systematic review.Frontiers in sports and active living · 2025Pooled it
- Effectiveness of exercise intervention on fall-related fractures in older adults: a systematic review and meta-analysis of randomized controlled trials.BMC geriatrics · 2020Pooled it
- Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults: A Systematic Review and Meta-analysis.JAMA internal medicine · 2019Pooled it
- Exercise effects on bone mineral density in older men: a systematic review with special emphasis on study interventions.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- The 2017 Dutch Physical Activity Guidelines.The international journal of behavioral nutrition and physical activity · 2018Pooled it
- Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia.GeroScience · 2021Trial
- Development and Validation of Accelerometer-Based Machine Learning Models for Classifying Walking, Running, and Jumping Activities.Sensors (Basel, Switzerland) · 2026Article
- Serum vitamin D levels and fall risk in adults: A cross-sectional study using the morse fall scale.PloS one · 2026Article
- Muscle-specific strength and its functional correlates in patients with osteosarcopenia.European geriatric medicine · 2025Article
- Reversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies.Journal of functional morphology and kinesiology · 2025Review
- Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).The journal of nutrition, health & aging · 2025Review
- The 2024 Guidelines for Osteoporosis - Korean Society of Menopause: Part I.Journal of menopausal medicine · 2024Review
- Lower-Body Fractures and the Risk of Dementia: A Nationwide Population-Based Study.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis.BMC musculoskeletal disorders · 2024Article
- Effects of bisphosphonates and treadmill exercise on bone and kidney in adenine-induced chronic kidney disease rats.Journal of bone and mineral metabolism · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIn this meta-analysis, we evaluated the effect of exercise on fracture reduction in the elderly. Our results determined a significantly positive effect on overall fractures, whereas the possibility of a publication bias indicates the need for well-designed (multi-center) trials that generate enough power to focus on osteoporotic fractures.
introductionThe preventive effect of exercise on fracture incidence has not been clearly determined yet. Thus, the purpose of this study is to evaluate the effectiveness of exercise in preventing overall and vertebral fractures in older adults by meta-analyses technique.
methodsThis study followed the PRISMA recommendations for systematic reviews and meta-analyses. A systematic review of English articles between 1980 and March 2012 was performed. Terms used were: "exercise", "fractures", "bone", "falls", "osteoporosis", "BMD", "BMC", "bone turnover", while the search was limited to "clinical trial" and "humans". Controlled exercise trials that reported fracture number as endpoint or observation in subjects 45 years and older were included.
resultsTen controlled exercise trials that reported overall fractures and three exercise trials that reported vertebral fractures met our inclusion criteria. Overall fracture number in the exercise group was 36 (n = 754) compared with 73 fractures in the CG (n = 670) (relative risk [RR] = 0.49; 95 % confidence interval [CI], 0.31-0.76). No significant heterogeneity of trial results (p = 0.28; I (2) = 17) was determined; however, there was some evidence to suggest a publication bias. The overall RR for vertebral fracture number (0.56; 95 % CI, 0.30-1.04) (EG: 19 fractures/103 subjects vs. CG: 31 fractures/102 subjects) was borderline non-significant while the heterogeneity of trial results also cannot be ruled out.
conclusionAlthough there is evidence that exercise reduces overall and, to a lesser degree, vertebral fractures in the elderly, the possibility of publication bias weakens our result and demonstrates the imperative for large exercise studies with dedicated exercise protocols that focus on fractures as a primary endpoint.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.