Evidence map›Paper›PMID 23306715›Full record

Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014

Effects of dexamethasone on local infiltration analgesia in total knee arthroplasty: a randomized controlled trial.

Masahiko Ikeuchi, Yuko Kamimoto, Masashi Izumi, Kayo Fukunaga, Koji Aso, Natsuki Sugimura, Masataka Yokoyama, Toshikazu Tani

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04051723 (Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-Craniotomy Pain in Children), which is not on this map. Cited by 58 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 10 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04051723 phase4completednot on this mapstarted 2019, after this paper: background citation

Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-Craniotomy Pain in Children

TypeinterventionalSponsorBeijing Tiantan HospitalRan2019 to 2020Enrolled80ConditionsPain, Postoperative, ChildrenArmsThe dexamethasone plus ropivacaine, The ropivacaine
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 10 syntheses or guidelines pooled it, 127 citations in OpenAlex.

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  8. The efficacy of steroid injection in total knee or hip arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015
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  10. Periarticular multimodal drug injection in total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Masahiko IkeuchiDepartment of Orthopedic Surgery, Kochi University, 185-1 Oko-cho, Nankoku, Kochi, 783-8505, Japan, ikeuchim@kochi-u.ac.jp.
Yuko Kamimoto
Masashi Izumi
Kayo Fukunaga
Koji Aso
Natsuki Sugimura
Masataka Yokoyama
Toshikazu Tani
Kōchi University · JPUniversity of Kochi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntraoperative local infiltration analgesia has gained increasing popularity in joint replacement surgery. Because there is considerable variation among drug combinations, analgesic effects of each drug are not well understood. The purpose of this study was to clarify the efficacy of the addition of steroid to local anaesthetics in local infiltration analgesia during total knee arthroplasty.

methodsForty patients were randomly allocated to the steroid or control group. Patients in the steroid group received peri-articular injection of ropivacaine, dexamethasone and isepamicin, while dexamethasone was omitted from the analgesic mixture in the control group. Primary outcome was pain severity at rest using 100 mm visual analogue scale.

resultsPain severity in the steroid group was lower than control group and there were significant differences between groups at post-operative day 1 and 3. Reduction in post-operative pain was associated with a decrease in serum C-reactive protein and interleukin 6 in drainage fluid. The number of patients who were able to perform straight leg raise within post-operative day 2 was 15/20 in the steroid group, which was significantly higher than the control group 5/20.

conclusionAdding steroid to local anaesthetics in local infiltration analgesia reduced inflammation both locally and systemically, resulting in significant early pain relief and rapid recovery in total knee arthroplasty.

Indexed as

AgedAmidesAnesthetics, LocalAnti-Bacterial AgentsAnti-Inflammatory AgentsArthroplasty, Replacement, KneeC-Reactive ProteinDexamethasoneFemaleGentamicinsHumansInjections, Intra-ArticularInterleukin-6MaleOsteoarthritis, KneePain ManagementAmidesAnesthetics, LocalAnti-Bacterial AgentsAnti-Inflammatory AgentsC-Reactive ProteinDexamethasoneGentamicinsInterleukin-6isepamicinRopivacaine

Identifiers

PMID23306715
OpenAlexW2018780188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.