Evidence map›Paper›PMID 23306713›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2013

Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics.

Giuseppe Filardo, Henning Madry, Mislav Jelic, Alice Roffi, Magali Cucchiarini, Elizaveta Kon

2 registry-linked trialsAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 103 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 8 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06164899 completednot on this mapstarted 2024, after this paper: background citation

Long-term Evaluation of Outcomes of Patients Undergoing Autologous Bone Marrow Concentrate Infiltration vs. Hyaluronic Acid for the Treatment of Bilateral Knee Osteoarthritis. Prospective Observational Study

TypeobservationalSponsorIstituto Ortopedico RizzoliRan2024 to 2025Enrolled60ConditionsKnee Osteoarthritis
NCT07422662 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Single-blind Randomized Study on the Arthroscopic Treatment of Acetabular Labral Lesions: Intrarticular Injection of Bone Marrow vs Hip Arthroscopy Alone

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2026 to 2032Enrolled80ConditionsFemoroAcetabular ImpingementArmsHip arthroscopy + BMAC injection, Hip arthroscopy
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 8 syntheses or guidelines pooled it, 234 citations in OpenAlex.

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  8. Stem cells in articular cartilage regeneration.Journal of orthopaedic surgery and research · 2016
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Giuseppe FilardoBiomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy.
Henning Madry
Mislav Jelic
Alice Roffi
Magali Cucchiarini
Elizaveta Kon
Istituto Ortopedico Rizzoli · ITSaarland University · DEOrthopedic Institute · USUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this systematic review is to examine the available clinical evidence in the literature to support mesenchymal stem cell (MSC) treatment strategies in orthopaedics for cartilage defect regeneration.

methodsThe research was performed on the PubMed database considering the English literature from 2002 and using the following key words: cartilage, cartilage repair, mesenchymal stem cells, MSCs, bone marrow concentrate (BMC), bone marrow-derived mesenchymal stem cells, bone marrow stromal cells, adipose-derived mesenchymal stem cells, and synovial-derived mesenchymal stem cells.

resultsThe systematic research showed an increasing number of published studies on this topic over time and identified 72 preclinical papers and 18 clinical trials. Among the 18 clinical trials identified focusing on cartilage regeneration, none were randomized, five were comparative, six were case series, and seven were case reports; two concerned the use of adipose-derived MSCs, five the use of BMC, and 11 the use of bone marrow-derived MSCs, with preliminary interesting findings ranging from focal chondral defects to articular osteoarthritis degeneration.

conclusionsDespite the growing interest in this biological approach for cartilage regeneration, knowledge on this topic is still preliminary, as shown by the prevalence of preclinical studies and the presence of low-quality clinical studies. Many aspects have to be optimized, and randomized controlled trials are needed to support the potential of this biological treatment for cartilage repair and to evaluate advantages and disadvantages with respect to the available treatments. LEVEL OF EVIDENCE: IV.

Indexed as

Mesenchymal Stem Cell TransplantationRegenerationAdipose TissueAnimalsCartilage, ArticularCells, CulturedHumansInjections, Intra-ArticularKnee InjuriesSynovial MembraneTissue Scaffolds

Identifiers

PMID23306713
OpenAlexW2062691873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.