ArticleEuropean radiology2013
The value of time-intensity curves obtained after microbubble contrast agent injection to discriminate responders from non-responders to anti-inflammatory medication among patients with Crohn's disease.
Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Bowel perfusion measured with dynamic contrast-enhanced ultrasound predicts treatment outcome in patients with Crohn's disease.Inflammatory bowel diseases · 2014Trial
- Real-time shear wave elastography in measuring normal ileocolon intestinal wall stiffness using colonoscopy as reference: A single-center research.European journal of radiology open · 2025Article
- B-mode ultrasound and dynamic contrast-enhanced ultrasound (DCE-US) of the bowel wall in patients with gastrointestinal food allergy in comparison to Crohn's disease and healthy controls.Ultrasound international open · 2025Article
- Contrast-Enhanced Endoscopic Ultrasound Detects Early Therapy Response Following Anti-TNF Therapy in Patients with Ulcerative Colitis.Journal of Crohn's & colitis · 2024Article
- Contrast-Enhanced Ultrasonography for the Evaluation of Crohn's Disease in Pediatric Patients.Journal of Korean medical science · 2023Article
- Contrast-enhanced ultrasound of the pediatric bowel.Pediatric radiology · 2021Review
- Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn's Disease. The State of the Art.Frontiers in pharmacology · 2021Review
- Correlation between ultrasound consolidated score and simple endoscopic score for determining the activity of Crohn's disease.The British journal of radiology · 2020Article
- US Molecular Imaging of Acute Ileitis: Anti-Inflammatory Treatment Response Monitored with Targeted Microbubbles in a Preclinical Model.Radiology · 2018Article
- SICUS and CEUS imaging in Crohn's disease: an update.Journal of ultrasound · 2017Review
- Dynamic Contrast-Enhanced Magnetic Resonance Enterography and Dynamic Contrast-Enhanced Ultrasonography in Crohn's Disease: An Observational Comparison Study.Ultrasound international open · 2017Article
- Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications.The British journal of radiology · 2017Review
- Dynamic contrast-enhanced ultrasound of the bowel wall with quantitative assessment of Crohn's disease activity in childhood.Radiology and oncology · 2016Article
- Update on Magnetic Resonance Imaging and Ultrasound Evaluation of Crohn's Disease.Gastroenterology & hepatology · 2016Article
- Conventional ultrasound and contrast-enhanced ultrasound in evaluating the severity of Crohn's disease.International journal of clinical and experimental medicine · 2015Article
- Contrast Enhanced Abdominal Ultrasound in the Assessment of Ileal Inflammation in Crohn's Disease: A Comparison with MR Enterography.PloS one · 2015Article
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Authors and funding
6 authors.
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Abstract
objectiveTo assess the value of time-intensity curves obtained after sulphur hefluoride-filled microbubble contrast agent injection to discriminate responders from non-responders among patients with Crohn's disease (CD).
methodsForty-three patients (29 male and 14 female; mean age ± SD, 48.5 ± 17.17 years) with initial diagnosis of active CD were recruited. In each patient, the therapeutic outcome was assessed after 12 weeks from the beginning of pharmacologic treatment. The terminal ileal loop was scanned after sulphur hexafluoride-filled microbubble injection, and the digital cine-clip registered during the first-pass dynamic enhancement was quantified in gray-scale levels. The percentage of maximal enhancement, time to peak enhancement, and area under the time-intensity curve in responders vs. non-responders were compared by Mann-Whitney U non-parametric test.
resultsResponders (n = 25 patients) vs. non-responders (n = 18) differed in the area under the time-intensity curve (621.58 ± 374.53 vs. 1,199.64 ± 386.39 P < 0.05), while they did not differ in percentage of maximal enhancement (41.26 ± 15.22 vs. 43.17 ± 4.41, P = 0.25) and time to peak enhancement (11.31 ± 3.06 vs. 10.12 ± 3.47, P = 0.15).
conclusionsThe area under the time-intensity curve obtained after microbubble injection was the only parameter to discriminate responders from non-responders among patients with CD during pharmacologic treatment. KEY POINTS: • Dynamic ultrasound using microbubble contrast agents can help assess inflammatory bowel disease • Time-intensity curves can assess therapeutic outcome in Crohn's disease (CD) • The area under the time-intensity curve differentiates responders from non-responders during pharmacological treatment.
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