ArticleIntensive care medicine2013
Relationship between respiratory impedance and positive end-expiratory pressure in mechanically ventilated neonates.
Article in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Respiratory oscillometry in infants: present challenges and future opportunities.Paediatric respiratory reviews · 2026Review
- Use of respiratory oscillometry in infants: a scoping review.Pediatric research · 2026Review
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 1: Inflammatory Modulation and Respiratory Impacts.Children (Basel, Switzerland) · 2026Review
- High PEEP Increases Airway Dead Space and Decreases Alveolar Ventilation: A New Technique for Volumetric Capnography.Biomedicines · 2025Article
- Lung function response to postnatal corticosteroids for the prevention and treatment of bronchopulmonary dysplasia.Pediatric research · 2025Observational
- Oscillometry Longitudinal Data on COVID-19 Acute Respiratory Syndrome Treated with Non-Invasive Respiratory Support.Journal of clinical medicine · 2024Article
- Combining lung ultrasound and oscillatory mechanics for assessing lung disease in very preterm infants.Pediatric research · 2024Observational
- Oscillometry for personalizing continuous distending pressure maneuvers: an observational study in extremely preterm infants.Respiratory research · 2024Observational
- A Novel CPAP Device With an Integrated Oxygen Concentrator for Low Resource Countries: In Vitro Validation and Usability Test in Field.IEEE open journal of engineering in medicine and biology · 2024Article
- Oscillatory mechanics trajectory in very preterm infants: a cohort study.Pediatric research · 2023Observational
- Clinical significance and applications of oscillometry.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Oscillatory mechanics at birth for identifying infants requiring surfactant: a prospective, observational trial.Respiratory research · 2021Observational
- Role of Lung Function Monitoring by the Forced Oscillation Technique for Tailoring Ventilation and Weaning in Neonatal ECMO: New Insights From a Case Report.Frontiers in pediatrics · 2018Article
- Year in review in Intensive Care Medicine 2013: III. Sepsis, infections, respiratory diseases, pediatrics.Intensive care medicine · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the feasibility of forced oscillation technique (FOT) measurements at the bedside and to describe the relationship between positive end-expiration pressure (PEEP) and lung mechanics in different groups of ventilated infants.
methodsTwenty-eight infants were studied: 5 controls, 16 newborns with respiratory distress syndrome (RDS) and 7 chronically ventilated newborns that developed bronchopulmonary dysplasia. An incremental/decremental PEEP trial was performed by changing PEEP in 1-min steps of 1 cmH(2)O between 2 and 10 cmH(2)O. Forced oscillations at 5 Hz were superimposed on the ventilator waveform. Pressure and flow, measured at the inlet of the ETT, were used to compute resistance (Rrs) and reactance (Xrs).
resultsIn controls Rrs and Xrs were on average 41 ± 21 and -22 ± 6 cmH(2)O s/l respectively and were almost unaffected by PEEP. RDS infants presented similar Rrs (48 ± 25 cmH(2)O s/l) and reduced Xrs (-71 ± 19 cmH(2)O s/l) at the beginning of the trial. Two behaviours were observed as PEEP was increased: in extremely low birth weight infants Xrs decreased with PEEP with marked hysteresis; in very low and low birth weight infants Xrs and Rrs were less PEEP dependent. Chronically ventilated infants had very high Rrs and very negative Xrs values at very low PEEPs (121 ± 41 and -95 ± 13 cmH(2)O s/l at PEEP = 2 cmH(2)O) that markedly changed as PEEP exceeded 3-4 cmH(2)O.
conclusionsRrs and Xrs measurement in preterm newborns is feasible, and data are representative of the lung mechanics and very sensitive to its changes with PEEP, making FOT a promising technique for the non-invasive bedside titration of mechanical ventilation in preterm newborns.
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