Evidence map›Paper›PMID 23306192›Full record

ReviewNutrients2013

Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation.

Matthias Wacker, Michael F Holick

Registry-linked trialAbstract readReview
In one paragraph

Review in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04986319 (The Level of Serum Vitamin D And Parathyroid Hormone Among Different Bangladeshi Population Groups), which is not on this map. Cited by 256 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04986319 completednot on this mapstarted 2017, after this paper: background citation

The Level of Serum Vitamin D And Parathyroid Hormone Among Different Bangladeshi Population Groups

TypeobservationalSponsorBangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic DisordersRan2017 to 2021Enrolled556ConditionsVitamin D DeficiencyArmsSerum vitamin D assay
3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Supplementation of Vitamin D in the Postdelivery Period of Women with Previous Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Trials.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021
    Pooled it
  3. Pooled it
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  7. Impact of vitamin D replacement in adults and elderly in the Middle East and North Africa: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Pooled it
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  13. Low-Dose Vitamin DFrontiers in immunology · 2021
    Trial
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  17. Article
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  19. Micronutrient deficiencies in hepatic cirrhosis: Navigating challenges to assessment and implications for clinical management: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  20. The Effect on Vitamin D Levels and VDR Gene Polymorphism on Clinical Outcomes in Asthma.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Article

196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthias WackerVitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, 85 East Newton Street, M-1013, Boston, MA 02118, USA. mwacker@bu.edu
Michael F Holick

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D, the sunshine vitamin, has received a lot of attention recently as a result of a meteoric rise in the number of publications showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some cancers, type 2 diabetes mellitus, cardiovascular disease and infectious diseases. Vitamin D deficiency is now recognized as a global pandemic. The major cause for vitamin D deficiency is the lack of appreciation that sun exposure has been and continues to be the major source of vitamin D for children and adults of all ages. Vitamin D plays a crucial role in the development and maintenance of a healthy skeleton throughout life. There remains some controversy regarding what blood level of 25-hydroxyvitamin D should be attained for both bone health and reducing risk for vitamin D deficiency associated acute and chronic diseases and how much vitamin D should be supplemented.

Indexed as

Skin Physiological PhenomenaSunlightAdultCardiovascular DiseasesChildDietary SupplementsFemaleFractures, BoneHumansMaleMuscle, SkeletalNeoplasmsOsteoporosisVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D

Identifiers

PMID23306192
PMCPMC3571641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.