Evidence map›Paper›PMID 23305908›Full record

ReviewExperimental eye research2013

Investigating mechanisms of myopia in mice.

Machelle T Pardue, Richard A Stone, P Michael Iuvone

Open access · greenAbstract readReview
In one paragraph

Review in Experimental eye research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 95 citations in OpenAlex.

  1. Circadian rhythms regulate refractive development across species.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Studies of All-trans Retinoic Acid Transport in the Eye.Investigative ophthalmology & visual science · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Neurophotonics · 2024
    Article
  9. Article
  10. Insights into Myopia from Mouse Models.Annual review of vision science · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Mice LackingInternational journal of molecular sciences · 2022
    Article
  16. Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia.Investigative ophthalmology & visual science · 2022
    Article
  17. Electroretinogram responses in myopia: a review.Documenta ophthalmologica. Advances in ophthalmology · 2022
    Review
  18. Article
  19. Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Machelle T PardueDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA. mpardue@emory.edu
Richard A Stone
P Michael Iuvone
Atlanta VA Medical Center · USEmory University · USPenn Presbyterian Medical Center · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H · 1986 to 2025
$15.3M
Neuromodulators and Circadian Clocks: Roles in Retinal Function and DysfunctionR01EY004864 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL · 1985 to 2018
$7.0M
Retinal Mechanisms of Refractive DevelopmentR01EY016435 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Machelle T. Pardue · 2009 to 2026
$5.4M
Molecular Characterization of Chick Retina during Refractive DevelopmentR01EY018838 · NEI · UNIVERSITY OF PENNSYLVANIA · PI STONE, RICHARD A · 2009 to 2010
$902k
NEI NIH HHS P30 EY001583NEI NIH HHS P30 EY006360NEI NIH HHS P30-EY006360NEI NIH HHS R01 EY004864NEI NIH HHS R01-EY004864NEI NIH HHS R01 EY016435NEI NIH HHS R01-EY016435NEI NIH HHS R01 EY018838NEI NIH HHS R01-EY018838
6 · The paper itself

Abstract

Genetic and environmental factors have been shown to control visually-guided eye growth and influence myopia development. However, investigations into the intersection of these two factors in controlling refractive development have been limited by the lack of a genetically modifiable animal model. Technological advances have now made it possible to assess refractive state and ocular biometry in the small mouse eye and therefore to exploit the many genetic mouse mutants to investigate mechanisms of visually-guided eye growth. This review considers the benefits and challenges of studying refractive development in mice, compares the results of refractive error and ocular biometry from wild-type strains and genetic models in normal laboratory visual environments or with disrupted visual input, and discusses some of the remaining challenges in interpreting data from the mouse to validate and standardize methods between labs.

Indexed as

Disease Models, AnimalAnimalsAxial Length, EyeBiometryEyeMiceMyopiaRefraction, OcularVision, Ocularaxial lengthc/dcycles per degreeDdiopterearly growth response proteinEgr-1emmetropiaform deprivationLCIlow coherence interferometermagnetic resonance imagingmembrane frizzled response proteinMfrpmouseMRImyopiaOCToptical coherence interferometryQTLquantitative trait locusrefractive developmentSD-OCTspectral domain-optical coherence interferometrywild typeWT

Identifiers

PMID23305908
PMCPMC3898884
OpenAlexW2110137584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.