ArticleEnvironmental science & technology2013
Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas).
Article in Environmental science & technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 89 citations in OpenAlex.
- Simultaneous determination of steroid hormones and pharmaceuticals in killer whale (Conservation physiology · 2023Article
- Triclosan is a KCNQ3 potassium channel activator.Pflugers Archiv : European journal of physiology · 2022Article
- Molecular evidence for suppression of swimming behavior and reproduction in the estuarine rotifer Brachionus koreanus in response to COVID-19 disinfectants.Marine pollution bulletin · 2022Article
- Article
- Genomic markers for the biological responses of Triclosan stressed hatchlings of Labeo rohita.Environmental science and pollution research international · 2021Article
- Effect of triclosan (TCS) on the protein content and associated histological changes on tilapia, Oreochromis mossambicus (Peters, 1852).Environmental science and pollution research international · 2021Article
- Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps.Scientific reports · 2020Article
- Toxicological responses, bioaccumulation, and metabolic fate of triclosan in Chlamydomonas reinhardtii.Environmental science and pollution research international · 2020Article
- DNA damage and physiological responses in an Indian major carp Labeo rohita exposed to an antimicrobial agent triclosan.Fish physiology and biochemistry · 2019Article
- Triclosan: An Update on Biochemical and Molecular Mechanisms.Oxidative medicine and cellular longevity · 2019Review
- Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats.Frontiers in molecular neuroscience · 2018Article
- Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabromobisphenol A.Molecular pharmacology · 2017Article
- Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA.Aquatic toxicology (Amsterdam, Netherlands) · 2015Article
- Perturbation and restoration of the fathead minnow gut microbiome after low-level triclosan exposure.Microbiome · 2015Article
- Structure-activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss).Aquatic toxicology (Amsterdam, Netherlands) · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Triclosan (TCS), a high volume chemical widely used in consumer products, is a known aquatic contaminant found in fish inhabiting polluted watersheds. Mammalian studies have recently demonstrated that TCS disrupts signaling between the ryanodine receptor (RyR) and the dihydropyridine receptor (DHPR), two proteins essential for excitation-contraction (EC) coupling in striated muscle. We investigated the swimming behavior and expression of EC coupling proteins in larval fathead minnows (Pimephales promelas) exposed to TCS for up to 7 days. Concentrations as low as 75 μg L(-1) significantly altered fish swimming activity after 1 day; which was consistent after 7 days of exposure. The mRNA transcription and protein levels of RyR and DHPR (subunit CaV1.1) isoforms changed in a dose and time dependent manner. Crude muscle homogenates from exposed larvae did not display any apparent changes in receptor affinity toward known radioligands. In nonexposed crude muscle homogenates, TCS decreased the binding of [(3)H]PN20-110 to the DHPR and decreased the binding of [(3)H]-ryanodine to the RyR, demonstrating a direct impact at the receptor level. These results support TCS's impact on muscle function in vertebrates further exemplifying the need to re-evaluate the risks this pollutant poses to aquatic environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.