ArticleJournal of cellular and molecular medicine2013
Facilitation of electroporative drug uptake and cell killing by electrosensitization.
Article in Journal of cellular and molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Pulsed Electric Fields for Emerging Single-Cell Bioprocessing in Food Applications: Electropermeabilization Mechanisms and Design Principles.Comprehensive reviews in food science and food safety · 2026Review
- Reassessing lidocaine as an electroporation sensitizer in vitro.Scientific reports · 2025Article
- Potentiation of Gelonin Cytotoxicity by Pulsed Electric Fields.International journal of molecular sciences · 2025Article
- Inactivation of antibiotic-resistant bacteriaFrontiers in microbiology · 2024Article
- In Vitro Imaging and Molecular Characterization of CaInternational journal of molecular sciences · 2023Article
- Micro- and Nanosecond Pulses Used in Doxorubicin Electrochemotherapy in Human Breast and Colon Cancer Cells with Drug Resistance.Molecules (Basel, Switzerland) · 2022Article
- Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy.Molecules (Basel, Switzerland) · 2021Review
- The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment-Case Study.Animals : an open access journal from MDPI · 2020Article
- The second phase of bipolar, nanosecond-range electric pulses determines the electroporation efficiency.Bioelectrochemistry (Amsterdam, Netherlands) · 2018Article
- Electropermeabilization of cells by closely spaced paired nanosecond-range pulses.Bioelectrochemistry (Amsterdam, Netherlands) · 2018Article
- Electrosensitization Increases Antitumor Effectiveness of Nanosecond Pulsed Electric FieldsTechnology in cancer research & treatment · 2017Article
- Delayed hypersensitivity to nanosecond pulsed electric field in electroporated cells.Scientific reports · 2017Article
- Selective susceptibility to nanosecond pulsed electric field (nsPEF) across different human cell types.Cellular and molecular life sciences : CMLS · 2017Article
- Avoiding the side effects of electric current pulse application to electroporated cells in disposable small volume cuvettes assures good cell survival.Cellular & molecular biology letters · 2017Article
- Electrosensitization assists cell ablation by nanosecond pulsed electric field in 3D cultures.Scientific reports · 2016Article
- Article
- Mathematical Models Describing Chinese Hamster Ovary Cell Death Due to Electroporation In Vitro.The Journal of membrane biology · 2015Article
- Diffuse, non-polar electropermeabilization and reduced propidium uptake distinguish the effect of nanosecond electric pulses.Biochimica et biophysica acta · 2015Article
- Gadolinium modifies the cell membrane to inhibit permeabilization by nanosecond electric pulses.Archives of biochemistry and biophysics · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell permeabilization by electric pulses (EP), or electroporation, is widely used for intracellular delivery of drugs and plasmids, as well as for tumour and tissue ablation. We found that cells pre-treated with 100-μs EP develop delayed hypersensitivity to subsequent EP applications. Sensitizing B16 and CHO cells by splitting a single train of eight 100-μs EP into two trains of four EP each (with 5-min. interval) decreased the LD(50) 1.5-2 times. Sensitization profoundly enhanced the electroporation-assisted uptake of bleomycin, a cell-impermeable cytotoxic agent accepted for killing tumours by electrochemotherapy. EP exposures that were not lethal per se caused cell death in the presence of bleomycin and proportionally to its concentration. Sensitizing cells by a split-dose EP exposure increased bleomycin-mediated lethality to the same extent as a 10-fold increase in bleomycin concentration when using a single EP dose. Likewise, sensitization by a split-dose EP exposure (without changing the overall dose, pulse number, or amplitude) enhanced the electroporative uptake of propidium up to fivefold. Enhancement of the electroporative uptake appears a key mechanism of electrosensitization and may benefit electrochemotherapy and numerous applications that employ EP for cell permeabilization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.