ArticleBMC cancer2013
Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series.
Article in BMC cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 62 citations in OpenAlex.
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- Breast Cancer Risk Assessment Tool (BCRAT) and long-term breast cancer mortality in the Women's Health Initiative.Breast cancer research and treatment · 2025Article
- Breast Cancer Mode of Detection in a Population-Based Cohort.Mayo Clinic proceedings · 2023Article
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- Cancer overdiagnosis: a challenge in the era of screening.Journal of the National Cancer Center · 2022Article
- Impact of the third national 'Be Clear on Cancer' Breast Cancer in Women over 70 Campaign on general practitioner attendance and referral, diagnosis rates and prevalence awareness.European journal of cancer care · 2022Article
- Breast Cancer Prevention: Time for Change.JCO oncology practice · 2021Article
- Triple-negative and HER2-positive breast cancers found by mammography screening show excellent prognosis.Breast cancer research and treatment · 2021Article
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- Self-reported symptoms among participants in a population-based screening program.Breast (Edinburgh, Scotland) · 2020Article
- Poor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahçeşehir (Istanbul) Breast Cancer Screening Project in Turkey.JCO global oncology · 2020Article
- Low Prevalence of HER2-Positive Breast Carcinomas among Screening Detected Breast Cancers.Cancers · 2020Article
- Factors Associated with Initial Mode of Breast Cancer Detection among Black Women in the Women's Circle of Health Study.Journal of oncology · 2019Article
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- Optical imaging of the breast: evaluation of deoxyhemoglobin concentration alteration in 166 patients with suspicious breast lesions.European radiology experimental · 2018Article
- Emerging Trends in Family History of Breast Cancer and Associated Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Differences in subtype distribution between screen-detected and symptomatic invasive breast cancer and their impact on survival.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
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14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStage shift is widely considered a major determinant of the survival benefit conferred by breast cancer screening. However, factors and mechanisms underlying such a prognostic advantage need further clarification. We sought to compare the molecular characteristics of screen detected vs. symptomatic breast cancers and assess whether differences in tumour biology might translate into survival benefit.
methodsIn a clinical series of 448 women with operable breast cancer, the Kaplan-Meier method and the log-rank test were used to estimate the likelihood of cancer recurrence and death. The Cox proportional hazard model was used for the multivariate analyses including mode of detection, age at diagnosis, tumour size, and lymph node status. These same models were applied to subgroups defined by molecular subtypes.
resultsScreen detected breast cancers tended to show more favourable clinicopathological features and survival outcomes compared to symptomatic cancers. The luminal A subtype was more common in women with mammography detected tumours than in symptomatic patients (68.5 vs. 59.0%, p=0.04). Data analysis across categories of molecular subtypes revealed significantly longer disease free and overall survival for screen detected cancers with a luminal A subtype only (p=0.01 and 0.02, respectively). For women with a luminal A subtype, the independent prognostic role of mode of detection on recurrence was confirmed in Cox proportional hazard models (p=0.03). An independent role of modality of detection on survival was also suggested (p=0.05).
conclusionsMolecular subtypes did not substantially explain the differences in survival outcomes between screened and symptomatic patients. However, our results suggest that molecular profiles might play a role in interpreting such differences at least partially.Further studies are warranted to reinterpret the efficacy of screening programmes in the light of tumour biology.
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