ArticleAIDS patient care and STDs2013
Co-morbidities in persons infected with HIV: increased burden with older age and negative effects on health-related quality of life.
Article in AIDS patient care and STDs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
191 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Impact of Dolutegravir-based regimens on patient satisfaction and quality of life among people living with HIV: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Health-Related Quality of Life in People with Advanced HIV Disease, from 1996 to 2021: Systematic Review and Meta-analysis.AIDS and behavior · 2024Pooled it
- Association of HIV infection and cognitive impairment in older adults: A meta-analysis.Ageing research reviews · 2021Pooled it
- Clinical determinants associated with quality of life for people who live with HIV/AIDS: a Meta-analysis.BMC health services research · 2019Pooled it
- Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol.BMC infectious diseases · 2017Pooled it
- Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol.BMC infectious diseases · 2016Pooled it
- Daily factors driving daily substance use and chronic pain among older adults with HIV: An exploratory study using ecological momentary assessment.Alcohol (Fayetteville, N.Y.) · 2019Trial
- Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging.Frontiers in immunology · 2018Trial
- CMV IgG and EBV Cell-Associated DNA Independently Associate With Veterans Aging Cohort Study Index 2.0 Scores in People With HIV on ART.The Journal of infectious diseases · 2026Article
- Association Between Changes in Socioeconomic Status Before and After Human Immunodeficiency Virus Infection Diagnosis and Mortality Rates in Korea.Journal of Korean medical science · 2026Article
- Analysis of Associated Factors and Construction of Risk Prediction Models for Frailty in Hospitalized Older Adults Living With HIV: Protocol for a Prospective Observational Study.JMIR research protocols · 2026Observational
- Effects of Two Anti-HIV-1 Regimens on Creatinine and Blood Lipids in Elderly People Living With HIV-1.AIDS research and treatment · 2026Article
- Antiretroviral Therapy Changes for Medicare Beneficiaries With HIV Transitioning to Long-Term Care.JAMA network open · 2025Article
- Estimation of Lifetime Costs Among Insured Persons with HIV in the United States.PharmacoEconomics - open · 2025Article
- Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3-5-year period.AIDS (London, England) · 2025Article
- Study characteristics on health-related quality of life in older people living with human immunodeficiency virus: A narrative review.World journal of virology · 2025Article
- Body mass index and hemophagocytic lymphohistiocytosis: a risk assessment in HIV-positive leukemia patients.Annals of medicine and surgery (2012) · 2025Review
- Predicting Trajectories of Everyday Functioning in Adults Aging with HIV Using Latent Growth Mixture Modeling.AIDS and behavior · 2025Article
- Health literacy mediates the association between cognition and healthcare provider interactions among gay and bisexual men with HIV disease.The Clinical neuropsychologist · 2025Article
- Disproportionate Vulnerability to and Unique Aggregation Pattern of Non-AIDS Comorbidities Among Women With HIV in China.Open forum infectious diseases · 2025Article
131 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
This study sought to determine the synergistic effects of age and HIV infection on medical co-morbidity burden, along with its clinical correlates and impact on health-related quality of life (HRQoL) across the lifespan in HIV. Participants included 262 individuals across four groups stratified by age (≤40 and ≥50 years) and HIV serostatus. Medical co-morbidity burden was assessed using a modified version of the Charlson Co-morbidity Index (CCI). Multiple regression accounting for potentially confounding demographic, psychiatric, and medical factors revealed an interaction between age and HIV infection on the CCI, with the highest medical co-morbidity burden in the older HIV+cohort. Nearly half of the older HIV+group had at least one major medical co-morbidity, with the most prevalent being diabetes (17.8%), syndromic neurocognitive impairment (15.4%), and malignancy (12.2%). Affective distress and detectable plasma viral load were significantly associated with the CCI in the younger and older HIV-infected groups, respectively. Greater co-morbidity burden was uniquely associated with lower physical HRQoL across the lifespan. These findings highlight the prevalence and clinical impact of co-morbidities in older HIV-infected adults and underscore the importance of early detection and treatment efforts that might enhance HIV disease outcomes.
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