ArticleBehavioral and brain functions : BBF2013
Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden.
Article in Behavioral and brain functions : BBF, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- PreclinicalMagnetic resonance in medicine · 2026Article
- Effects of acute biperiden treatment following traumatic brain injury in male rats.Scientific reports · 2025Article
- Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration.Nature reviews. Neuroscience · 2025Review
- A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency.Cell reports. Medicine · 2022Article
- Multimodal characterization of Yucatan minipig behavior and physiology through maturation.Scientific reports · 2021Article
- Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat.Psychopharmacology · 2018Article
- Better, Not Just More-Contrast in Qualitative Aspects of Reward Facilitates Impulse Control in Pigs.Frontiers in psychology · 2018Article
- Judgement bias in pigs is independent of performance in a spatial holeboard task and conditional discrimination learning.Animal cognition · 2017Article
- Translational models for vascular cognitive impairment: a review including larger species.BMC medicine · 2017Review
- Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation.Frontiers in psychiatry · 2017Review
- Vascular Contributions to Cognitive Impairment and Dementia: Topical Review of Animal Models.Stroke · 2016Review
- Effects of environmental enrichment on cognitive performance of pigs in a spatial holeboard discrimination task.Animal cognition · 2016Article
- Article
- Overnight Social Isolation in Pigs Decreases Salivary Cortisol but Does Not Impair Spatial Learning and Memory or Performance in a Decision-Making Task.Frontiers in veterinary science · 2015Article
- Early Life in a Barren Environment Adversely Affects Spatial Cognition in Laying Hens (Gallus gallus domesticus).Frontiers in veterinary science · 2015Article
- Chronic allopurinol treatment during the last trimester of pregnancy in sows: effects on low and normal birth weight offspring.PloS one · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pig is emerging as a model species that bridges the gap between rodents and humans in research. In particular, the miniature pig (referred to hereafter as the minipig) is increasingly being used as non-rodent species in pharmacological and toxicological studies. However, there is as yet a lack of validated behavioral tests for pigs, although there is evidence that the spatial holeboard task can be used to assess the working and reference memory of pigs. In the present study, we compared the learning performance of commercial pigs and Göttingen minipigs in a holeboard task.
methodsBiperiden, a muscarinic M1 receptor blocker, is used to induce impairments in cognitive function in animal research. The two groups of pigs were treated orally with increasing doses of biperiden (0.05 - 20 mg.kg-1) after they had reached asymptotic performance in the holeboard task.
resultsBoth the conventional pigs and the Göttingen minipigs learned the holeboard task, reaching nearly errorless asymptotic working and reference memory performance within approximately 100 acquisition trials. Biperiden treatment affected reference, but not working, memory, increasing trial duration and the latency to first hole visit at doses ≥ 5 mg.kg-1.
conclusionBoth pig breeds learned the holeboard task and had a comparable performance. Biperiden had only a minor effect on holeboard performance overall, and mainly on reference memory performance. The effectiveness needs to be evaluated further before definitive conclusions can be drawn about the ability of this potential cognition impairer in pigs.
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