ArticleJournal of thyroid research2012
TSH Measurement and Its Implications for Personalised Clinical Decision-Making.
Article in Journal of thyroid research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Metabolic and hepatic differences among biochemically euthyroid individuals with distinct thyroid hormone sources: a comparative study.BMC endocrine disorders · 2026Article
- Thyroid Function Test Abnormalities in Human Immunodeficiency Virus Positive Patients on Antiretroviral Therapy at Matyazo Health Center, Huye, Rwanda.Rwanda journal of medicine and health sciences · 2025Article
- Comparison of Enzyme-Linked Immunosorbent Assay and Lateral Flow Assay to Measure Thyroid-Stimulating Hormone and Free T4 in Human Serum.Journal of clinical laboratory analysis · 2025Article
- Hormonal computing: a conceptual approach.Frontiers in chemistry · 2023Article
- Need for Completion Thyroidectomy in Patients Undergoing Lobectomy for Indeterminate and High-Risk Nodules: Impact of Intra-Operative Findings and Final Pathology.World journal of surgery · 2020Article
- Artificial intelligence may offer insight into factors determining individual TSH level.PloS one · 2020Article
- Relationship between thyroid dysfunction and body weight: a not so evident paradigm.International journal of general medicine · 2019Article
- Individualised requirements for optimum treatment of hypothyroidism: complex needs, limited options.Drugs in context · 2019Review
- Predictors of Postoperative Diabetes Insipidus Following Endoscopic Resection of Pituitary Adenomas.Journal of the Endocrine Society · 2018Article
- Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth.The Journal of clinical endocrinology and metabolism · 2018Article
- Recent Advances in Thyroid Hormone Regulation: Toward a New Paradigm for Optimal Diagnosis and Treatment.Frontiers in endocrinology · 2017Review
- Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine.PloS one · 2017Article
- Relational Stability in the Expression of Normality, Variation, and Control of Thyroid Function.Frontiers in endocrinology · 2016Review
- Homeostatic Control of the Thyroid-Pituitary Axis: Perspectives for Diagnosis and Treatment.Frontiers in endocrinology · 2015Review
- Interrelations between thyrotropin levels and iodine status in thyroid-healthy children.Thyroid : official journal of the American Thyroid Association · 2014Article
- TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.Journal of thyroid research · 2012Article
- Thyroid Function Test in Preterm Neonates: Normative Data.Indian journal of endocrinology and metabolismArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in assay technology have promoted thyrotropin (TSH) measurements from participation in a multi-analyte assessment of thyroid function to a statistically defined screening parameter in its own right. While this approach has been successful in many ways, it has some grave limitations. This includes the basic question of what constitutes an agreed reference range and the fact that the population-based reference range by far exceeds the variation of the intraindividual set point. Both problems result in a potential misdiagnosis of normal and pathological thyroid function in a substantial proportion of patients. From a physiological perspective, TSH plays an integrated role in thyroid homeostasis. Few attempts have been made to adopt physiological insights into thyroid homeostasis for medical decision-making. Some emerging novel findings question the widely assumed log-linear TSH-FT(4) relationship over the entire thyroid function spectrum. This data favours more complex hierarchically structured models. With a better understanding of its role in thyroid homeostasis in thyroid health and disease, TSH can be revisited in the context of thyroid regulation. This, in turn, could help overcome some of the limitations arising from its isolated statistical use and offer new prospects towards a more personalised interpretation of thyroid test results.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.