ArticleJournal of aging research2012
Potential moderators of physical activity on brain health.
Article in Journal of aging research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial.Alzheimer's research & therapy · 2020Trial
- Brain Training Games Enhance Cognitive Function in Healthy Subjects.Medical science monitor basic research · 2018Trial
- Cardiorespiratory fitness is associated with cognitive function in late adulthood: baseline findings from the IGNITE study.British journal of sports medicine · 2025Article
- Dietary patterns and cardiorespiratory fitness in midlife and subsequent all-cause dementia: findings from the cooper center longitudinal study.The international journal of behavioral nutrition and physical activity · 2024Article
- Effect of exercise engagement and cardiovascular risk on neuronal injury.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer's disease risk? A novel integrative model.Alzheimer's research & therapy · 2023Review
- Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study.Brain sciences · 2021Article
- Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project.Journal of clinical medicine · 2020Article
- The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive Illness in the Elderly.Current neuropharmacology · 2018Review
- Relationships Between Aerobic Fitness Levels and Cognitive Performance in Swedish Office Workers.Frontiers in psychology · 2018Article
- Aging Adventure Athletes Assess Achievements and Alter Aspirations to Maintain Self-Esteem.Frontiers in psychology · 2018Article
- Mediators of Physical Activity on Neurocognitive Function: A Review at Multiple Levels of Analysis.Frontiers in human neuroscience · 2016Review
- Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder.Frontiers in aging neuroscience · 2015Article
- Physical activity, fitness, and gray matter volume.Neurobiology of aging · 2014Review
- A review of cardiorespiratory fitness-related neuroplasticity in the aging brain.Frontiers in aging neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Age-related cognitive decline is linked to numerous molecular, structural, and functional changes in the brain. However, physical activity is a promising method of reducing unfavorable age-related changes. Physical activity exerts its effects on the brain through many molecular pathways, some of which are regulated by genetic variants in humans. In this paper, we highlight genes including apolipoprotein E (APOE), brain derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) along with dietary omega-3 fatty acid, docosahexaenoic acid (DHA), as potential moderators of the effect of physical activity on brain health. There are a growing number of studies indicating that physical activity might mitigate the genetic risks for disease and brain dysfunction and that the combination of greater amounts of DHA intake with physical activity might promote better brain function than either treatment alone. Understanding whether genes or other lifestyles moderate the effects of physical activity on neurocognitive health is necessary for delineating the pathways by which brain health can be enhanced and for grasping the individual variation in the effectiveness of physical activity interventions on the brain and cognition. There is a need for future research to continue to assess the factors that moderate the effects of physical activity on neurocognitive function.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.